DNA repair: Polymerases for passing lesions

Slides:



Advertisements
Similar presentations
CH 11: DNA Replication Complementarity ”It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying.
Advertisements

Chapter 12.3 (Pgs: ): DNA Replication. The Replication Process 1.DNA separates into two strands -Accomplished by the enzyme helicase -Creates a.
Chromosome Structure and DNA Replication
Chromosomes and DNA replication. Procaryotes : DNA is in the cytoplasm, circular Chromosome E. Coli Bacterium Bases on the Chromosomes.
SOS response in E. coli By Dan Wilson. SOS response in E. coli  The bacterium is exposed to something that damages its DNA. For example: Radiation or.
DNA Replication 17 September Note: On all figures: Template strand (parental DNA) in orange Primer strand (newly synthesized DNA) in red.
Sezgin Gunes, Maha Al-Sadaan, Ashok Agarwal 
Volume 13, Issue 13, Pages R514-R516 (July 2003)
DNA Replication.
Volume 8, Issue 9, Pages R177-R185 (September 2000)
RNA-Directed DNA Methylation: Getting a Grip on Mechanism
Indigenous microflora: Paving the way for pathogens?
Shelterin Current Biology
RNA processing and transport RNA degradation Translation
DNA Replication Reaches the Breaking Point
DNA Replication pp
Semiconservative Replication of DNA
Chromatin replication: Finding the right connection
RNA ACTIVE FIGURE General features of a replication fork ACTIVE FIGURE General features of a replication fork. The DNA duplex is unwound.
Oh what a tangled web it weaves: BRCA1 and DNA decatenation
DNA Polymerase III: Running Rings around the Fork
Prediction of protein structure
Chapter 13 DNA Replication.
A ring to bind eukaryotic DNA polymerase
Saving the Ends for Last: The Role of Pol μ in DNA End Joining
Dana Branzei, Marco Foiani  Cell 
DNA-Mismatch Repair: The intricacies of eukaryotic spell-checking
DNA Polymerases at the Replication Fork in Eukaryotes
Fanconi anemia pathway
Fungal BRCA2 Ortholog Brh2 Brings 5′ End Strand Invasion Back on Stage
More Division of Labor at the Eukaryotic Replication Fork
Chromosomal DNA Replication on a Protein “Chip”
Sex Determination: Balancing Selection in the Honey Bee
Volume 2, Issue 1, Pages 2-4 (July 2002)
Sezgin Gunes, Maha Al-Sadaan, Ashok Agarwal 
DNA-Cation Interactions
DNA Replication: Keep Moving and Don't Mind the Gap
Bacterial conjugation: Running rings around DNA
Meiotic Checkpoints: Repair or Removal?
In DNA Replication, the Early Bird Catches the Worm
Sliding clamps: A (tail)ored fit
Volume 16, Issue 14, Pages (July 2006)
Chromosome cohesion: A polymerase for chromosome bridges
DNA Replication AP Biology Ch 16.2.
Need for Speed: Mechanical Regulation of a Replicative Helicase
Elizabeth S Egan, Anders Løbner-Olesen, Matthew K Waldor 
Volume 15, Issue 13, Pages R483-R484 (July 2005)
Figure 16.7 A model for DNA replication: the basic concept (Layer 4)
DNA Replication Fidelity: Proofreading in Trans
Volume 23, Issue 7, Pages R273-R276 (April 2013)
Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes
DNA repair: Rad52 – the means to an end
Telomeres: The Molecular Events Driving End-To-End Fusions
Polymerase Stalling during Replication, Transcription and Translation
Synaptic plasticity: Keeping synapses under control
Volume 7, Issue 6, Pages R147-R151 (June 2000)
Polymerase Switching in DNA Replication
SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair
Rad52  Uffe H. Mortensen, Michael Lisby, Rodney Rothstein 
Inteins Current Biology
Volume 21, Issue 9, Pages (September 2014)
Errol C Friedberg, Valerie L Gerlach  Cell 
Self-replication Current Biology Volume 13, Issue 2, (January 2003)
Horizontal Gene Transfer: Accidental Inheritance Drives Adaptation
DNA damage, DNA repair and disease
Selfish DNA: Homing Endonucleases Find a Home
FANCD2 Hurdles the DNA Interstrand Crosslink
Volume 21, Issue 9, Pages (September 2014)
Volume 18, Issue 5, Pages R198-R202 (March 2008)
Bacterial chemotaxis Current Biology
Presentation transcript:

DNA repair: Polymerases for passing lesions Bryn A. Bridges  Current Biology  Volume 9, Issue 13, Pages R475-R477 (July 1999) DOI: 10.1016/S0960-9822(99)80299-1

Figure 1 Four ways of dealing with a damaged DNA base at the replication fork. For simplicity, the figure shows only the template strand with the damaged base. Homology exists between E. coli UmuD protein, yeast polymerase η and yeast and human polymerase ζ suggesting that there is considerable mechanistic conservation between bacteria and humans. Current Biology 1999 9, R475-R477DOI: (10.1016/S0960-9822(99)80299-1)