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Potential Role of γδ T Cell-Derived IL-17 in Acute Cardiac Allograft Rejection Naoyuki Kimura, MD, Susumu Nakae, PhD, Satoshi Itoh, MD, Denis R. Merk, MD, Xi Wang, MD, PhD, Yongquan Gong, MD, Homare Okamura, MD, Paul A. Chang, BS, Hideo Adachi, MD, PhD, Robert C. Robbins, MD, Michael P. Fischbein, MD, PhD The Annals of Thoracic Surgery Volume 94, Issue 2, Pages 542-548 (August 2012) DOI: 10.1016/j.athoracsur.2012.03.049 Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Cellular profile in allografts from wild type (WT) and T-cell receptor (TCR)δ−/− recipients on postoperative day 6. Proportion of CD3+γδTCR+ cells in 7-aminoactinomycin-D-negative CD45+cells. The CD3+γδTCR+quadrant was used for quantitative analysis shown in Table 1. Graphs illustrate representative flow cytometry results from 6 independent experiments. The Annals of Thoracic Surgery 2012 94, 542-548DOI: (10.1016/j.athoracsur.2012.03.049) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Increased Treg expression in allografts transplanted into T-cell receptor (TCR)δ−/− recipients during acute rejection. Allografts (FVB hearts) were harvested from B6-wild type (WT) or B6-TCRδ−/− recipient mice on postoperative days 8, 30, and 60. The proportion of CD25+Foxp3+Tregs in CD4+T cells from single cell suspension of allografts was determined by flow cytometry analysis. The Annals of Thoracic Surgery 2012 94, 542-548DOI: (10.1016/j.athoracsur.2012.03.049) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Total number of interleukin (IL)-17 producing CD4, γδ T cell, Vγ1+, and Vγ4+T cells from allografts transplanted into wild type recipients on postoperative day 6 (n = 6). Data show mean ± standard error of the mean. The Annals of Thoracic Surgery 2012 94, 542-548DOI: (10.1016/j.athoracsur.2012.03.049) Copyright © 2012 The Society of Thoracic Surgeons Terms and Conditions