Development I. History A. Epigenesis B. Pre-formation The Homunculus B. Pre-formation C. Blending vs. Mixing D. Current Thoughts

II. Fertilization A. Male Duties 1. Acrosomal Activities 2. Getting There

B. Female Duties 1. Acrosomal Reaction (fast block to polyspermy) Figure 47.3 Figure 47.4

2. Cortical Reaction (slow block to polyspermy) Figure 47.4 Figure 11.14

III. Post-Fertilization Stages A. Cleavage 1. Patterns  Radial vs. Spiral Figure 47.7 Figure 32.10

Fertilized 16 cell 64 cell Blastula Figure 47.22

2. Polarity (Animal vs. Vegetal Pole) Figure 47.22 Figure 47.7

B. Gastrulation 1. Strategies Figure 32.9 Figure 47.8

Figure 47.10 2. Outcomes Figure 47.9

C. Organogenesis 1. What comes first? Figure 47.14

IV. Amniote Development A. Avians 1. What’s going on inside the egg? Figure 47.15a Figure 47.13

Figure 47.15b

B. Mammals 1. What’s going on inside the womb? Figure 47.12

V. Morphogenesis A. Changes 1. Intra-cellular Figure 47.17

2. Extra-cellular

B. Fate Mapping Figure 47.18a Figure 47.23

C. Inductive Signaling Figure 47.26 Figure 47.25 Figure 47.24