Calcitonin gene-related peptide– and vascular endothelial growth factor–positive inflammatory cells in late-phase allergic skin reactions in atopic subjects

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Calcitonin gene-related peptide– and vascular endothelial growth factor–positive inflammatory cells in late-phase allergic skin reactions in atopic subjects A. Barry Kay, MD, PhD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 232-237 (January 2011) DOI: 10.1016/j.jaci.2010.10.028 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The effect of allergen challenge on the accumulation of CGRP+ cells in 6-hour skin biopsy specimens. A, Immunopositive cells; B, mRNA-positive cells. Statistical comparisons of diluent and allergen sites were performed by using 2-tailed Wilcoxon signed-rank tests. C and D, Photomicrographs (×400 magnification) of an allergen-injected (Fig 1, C) and a diluent-injected (Fig 1, D) site are also shown. Journal of Allergy and Clinical Immunology 2011 127, 232-237DOI: (10.1016/j.jaci.2010.10.028) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The effect of allergen challenge on the accumulation of VEGF+ cells in 6- and 24-hour skin biopsy specimens. Statistical comparisons of diluent (Dil) and allergen (Ag) sites were performed by using 2-tailed Wilcoxon signed-rank tests. Photomicrographs (×10 magnification) of an allergen-injected (bottom left) and a diluent-injected (bottom right) site are shown. A higher (×400) magnification is shown in the inset. Journal of Allergy and Clinical Immunology 2011 127, 232-237DOI: (10.1016/j.jaci.2010.10.028) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The time course of infiltration of CGRP+ cells compared with the magnitude of the late-phase skin reaction at intervals up to 72 hours. Counts are expressed as cell numbers per square millimeter. Dil, Diluent. Journal of Allergy and Clinical Immunology 2011 127, 232-237DOI: (10.1016/j.jaci.2010.10.028) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Colocalization of CGRP immunoreactivity to CD3+ and neutrophil elastase (NE)–positive cells. The numbers of double-positive cells are shown (top left), and the percentage of the 2 cell types that are CGRP+ is shown (top right). Colocalization of CGRP to CD3+ T cells (bottom left) and neutrophil elastase–positive cells (bottom right) is also shown. Single CD3+ or neutrophil elastase–positive cells (green) and single CGRP cells (red) are shown. Double-positive cells (yellow/green) are indicated by arrows. Journal of Allergy and Clinical Immunology 2011 127, 232-237DOI: (10.1016/j.jaci.2010.10.028) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Colocalization of VEGF immunoreactivity to inflammatory cells. The percentage of cell types that are VEGF+ are shown in A, and the percentage of total VEGF+ cells are shown in B. Colocalization of VEGF to major basic protein (MBP)–positive cells (bottom left) and CD68+ macrophages (bottom right) is shown. Single major basic protein–positive or CD68+ cells (green) and single VEGF cells (red) are illustrated, and the double-positive cells (yellow/green) are indicated by arrows. EO, Eosinophils; NE, neutrophil elastase. Journal of Allergy and Clinical Immunology 2011 127, 232-237DOI: (10.1016/j.jaci.2010.10.028) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions