Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer

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Presentation transcript:

Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer Ivan Roa, Hernan Garcia, Anakaren Game, Gonzalo de Toro, Xabier de Aretxabala, Milind Javle The Journal of Molecular Diagnostics Volume 18, Issue 3, Pages 388-394 (May 2016) DOI: 10.1016/j.jmoldx.2015.12.003 Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 Results of the exons 9 and 20 amplification on agarose gels. Electropherogram shows a point mutation E542K with substitution of G>A (red arrow). The Journal of Molecular Diagnostics 2016 18, 388-394DOI: (10.1016/j.jmoldx.2015.12.003) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 Actuarial survival of the study group. The marked difference is observed between early and advanced stages of the gallbladder cancer. Eighty-five percent of patients with compromise of serosa or beyond had died within the first 15 months after diagnosis. P = 0.001. The Journal of Molecular Diagnostics 2016 18, 388-394DOI: (10.1016/j.jmoldx.2015.12.003) Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions