Cardiac remodeling and dysfunction in nephrotic syndrome

Slides:

Advertisements

Similar presentations

Renin-stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells Y. Huang, N.A. Noble, J. Zhang, C. Xu, W.A.

Advertisements

Volume 70, Issue 8, Pages (October 2006)

Volume 65, Issue 4, Pages (April 2004)

Volume 70, Issue 3, Pages (August 2006)

Germaine Wong, Jeremy R. Chapman, Jonathan C. Craig

Volume 56, Issue 4, Pages (October 1999)

Volume 71, Issue 11, Pages (June 2007)

Volume 69, Issue 4, Pages (February 2006)

GAPDH as housekeeping gene at renal level

Volume 71, Issue 10, Pages (May 2007)

Volume 72, Issue 1, Pages (July 2007)

Volume 63, Issue 1, Pages (January 2003)

Renin-stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells Y. Huang, N.A. Noble, J. Zhang, C. Xu, W.A.

Volume 75, Issue 10, Pages (May 2009)

Karl A. Nath, Anthony J. Croatt, Jill J. Haggard, Joseph P. Grande

Intestinal phosphate absorption in a model of chronic renal failure

Proinflammatory effects of iron sucrose in chronic kidney disease

Volume 72, Issue 8, Pages (October 2007)

Volume 70, Issue 11, Pages (December 2006)

Insulin resistance in African Americans

Volume 57, Issue 5, Pages (May 2000)

Volume 69, Issue 6, Pages (March 2006)

17-β Estradiol attenuates streptozotocin-induced diabetes and regulates the expression of renal sodium transporters S. Riazi, C. Maric, C.A. Ecelbarger

Volume 71, Issue 6, Pages (March 2007)

Local delivery of angiotensin receptor blocker into the kidney ameliorates progression of experimental glomerulonephritis J. Mahmood, F. Khan, S. Okada,

Blood pressure targets in hemodialysis patients

Volume 69, Issue 10, Pages (May 2006)

Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis M. Hagiwara, K. Yamagata, R.A. Capaldi, A. Koyama

The third World Kidney Day: Looking back and thinking forward

Volume 70, Issue 1, Pages (July 2006)

Volume 71, Issue 9, Pages (May 2007)

Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis H.-C. Yang, L.-J. Ma, J. Ma, A.B. Fogo

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Volume 70, Issue 8, Pages (October 2006)

M.-J. Wu, M.-C. Wen, Y.-T. Chiu, Y.-Y. Chiou, K.-H. Shu, M.-J. Tang

Volume 68, Issue 5, Pages (November 2005)

Volume 69, Issue 11, Pages (June 2006)

Increased workload fully activates the blunted IRS-1/PI3-kinase/Akt signaling pathway in atrophied uremic muscle Y. Chen, S. Sood, J. Biada, R. Roth,

Kaihui Liang, Nosratola D. Vaziri Kidney International

Volume 69, Issue 11, Pages (June 2006)

Volume 71, Issue 4, Pages (February 2007)

Volume 71, Issue 11, Pages (June 2007)

H. Raffi, J.M. Bates, Z. Laszik, S. Kumar Kidney International

Endothelin antagonists in renal disease

Phosphate binders on iron basis: A new perspective?

Organ transplantation goes to the movies

Nosratola D. Vaziri, M.D., Kaihui Liang Kidney International

Volume 72, Issue 3, Pages (August 2007)

Diagnosing Alport syndrome using electron microscopy of the skin

Volume 57, Issue 6, Pages (June 2000)

Volume 68, Pages S98-S102 (December 2005)

Is it the low-protein diet or simply the salt restriction?

Volume 70, Issue 8, Pages (October 2006)

Volume 70, Issue 3, Pages (August 2006)

Volume 70, Issue 3, Pages (August 2006)

Volume 71, Issue 9, Pages (May 2007)

Volume 70, Issue 5, Pages (September 2006)

Volume 62, Issue 5, (November 2002)

Increased renal calcium and magnesium transporter abundance in streptozotocin- induced diabetes mellitus C-T. Lee, Y-H.H. Lien, L-W. Lai, J-B. Chen, C-R.

IL-1β induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells D. Solà-Villà, M. Camacho, R. Solà,

T cells and T-cell receptors in acute renal failure

The International Pediatric Peritonitis Registry: Starting to walk

T-PA promotes glomerular plasmin generation and matrix degradation in experimental glomerulonephritis Masashi Haraguchi, Wayne A. Border, Yufeng Huang,

Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia S. Faroqui, M. Levi,

Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Acute nephrotoxic and obstructive injury primes the kidney to endotoxin-driven cytokine/chemokine production R.A. Zager, A.C.M. Johnson, S.Y. Hanson,

Volume 65, Issue 6, Pages (June 2004)

Volume 70, Issue 1, Pages (July 2006)

Volume 71, Issue 3, Pages (February 2007)

Presentation transcript:

Cardiac remodeling and dysfunction in nephrotic syndrome M. Moreira-Rodrigues, R. Roncon-Albuquerque, T. Henriques-Coelho, A.-P. Lourenço, B. Sampaio-Maia, J. Santos, M. Pestana, A.-F. Leite-Moreira Kidney International Volume 71, Issue 12, Pages 1240-1248 (June 2007) DOI: 10.1038/sj.ki.5002204 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Urinary excretion of sodium and urinary levels of noradrenaline in PAN and Control rats throughout the study. *P<0.05 vs Control rats. Kidney International 2007 71, 1240-1248DOI: (10.1038/sj.ki.5002204) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Histology of the left ventricle (LV) and gastrocnemius muscle in PAN nephrosis, 14 days after injection. Cell transversal diameter of (a) cardiac (original magnification × 400 amplification, left ventricle) and (b) gastrocnemius muscle (original magnification × 200 amplification) cells, with respectively representative photographs. *P<0.05 vs control rats. Kidney International 2007 71, 1240-1248DOI: (10.1038/sj.ki.5002204) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 3 FFRs obtained in multicellular muscle preparations from the LV myocardium in PAN nephrosis, 14 days after injection. Results are presented as percent variation from baseline AT at 0.5Hz. †P<0.05 for interaction with two-way repeated measures analysis of variance; *P<0.05 vs Control rats at an equivalent frequency of stimulation; ‡P<0.05 vs 1Hz, as evaluated with the Student–Newman–Keuls method for multiple group comparisons. Kidney International 2007 71, 1240-1248DOI: (10.1038/sj.ki.5002204) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 4 LV mRNA expression in PAN nephrosis, 7 and 14 days after injection. The following genes were studied: (a) TNF-α, IL-1β, and IL-1α; (b) BNP, pre-pro-endothelin 1 (ppET-1), and IGF-1; (c) IL-6, MHC-α, and MHC-β and (d) SERCA2a, PLB, and Na+/Ca2+ exchanger (NCX). Results are expressed as AUs after normalization for GAPDH. The AU was set as the average value of the Control group and is presented as a reference line. *P<0.05 vs Control rats. Kidney International 2007 71, 1240-1248DOI: (10.1038/sj.ki.5002204) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 5 LV protein levels of SERCA2a (110kDa) and total PLB (pentamer 25kDa plus monomer 10kDa), with respectively representative immunoblots, and SERCA2a to PLB ratio in PAN nephrosis, 14 days after injection. Results are expressed as AUs after normalization for GAPDH protein. The AU was set as the average value of the Control group. p, PLB pentamer and m, PLB monomer. *P<0.05 vs Control rats. Kidney International 2007 71, 1240-1248DOI: (10.1038/sj.ki.5002204) Copyright © 2007 International Society of Nephrology Terms and Conditions