M. Kokki, P. Välitalo, M. Kuusisto, V. P. Ranta, K. Raatikainen, H

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Presentation transcript:

Central nervous system penetration of oxycodone after intravenous and epidural administration M. Kokki, P. Välitalo, M. Kuusisto, V.P. Ranta, K. Raatikainen, H. Hautajärvi, H. Kokki British Journal of Anaesthesia Volume 112, Issue 1, Pages 133-140 (January 2014) DOI: 10.1093/bja/aet337 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Consort flow diagram. British Journal of Anaesthesia 2014 112, 133-140DOI: (10.1093/bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 (a) Plasma and (b) CSF concentration of oxycodone after i.v. administration. The median (range) dose of oxycodone hydrochloride was 0.092 (0.079–0.097) mg kg−1, administered as a 5 min infusion. British Journal of Anaesthesia 2014 112, 133-140DOI: (10.1093/bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 (a) Plasma and (b) CSF concentration of oxycodone after epidural administration. The median (range) dose of oxycodone hydrochloride was 0.093 (0.086–0.100) mg kg−1, administered as a 5 min infusion. The CSF concentration of 10 000 ng ml−1 means that the true concentration was above this upper limit of quantification. British Journal of Anaesthesia 2014 112, 133-140DOI: (10.1093/bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 Rescue analgesic doses of i.v. fentanyl in the two groups during the first four postoperative hours. Each hatched line corresponds to a single subject and each dot a single rescue dose of i.v. fentanyl. British Journal of Anaesthesia 2014 112, 133-140DOI: (10.1093/bja/aet337) Copyright © 2014 The Author(s) Terms and Conditions