Glioma Development: Where Did It All Go Wrong?

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Glioma Development: Where Did It All Go Wrong? Kumar Sukhdeo, Dolores Hambardzumyan, Jeremy N. Rich Cell Volume 146, Issue 2, Pages 187-188 (July 2011) DOI: 10.1016/j.cell.2011.06.047 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 MADM Identifies Cell of Origin in Glioma (A) The hierarchy of NSC differentiation. MADM recombination in dividing NSCs resulting in p53/Nf1 inactivation also labels mutant cells with GFP. RFP-labeled cells undergo alternative recombination to become wild-type for p53 and Nf1. Despite a shared genetic background in all mutant NSC-derived lineages, only OPCs expand and give rise to glioma. (B) Gliomagenesis also occurs when p53/Nf1 inactivation is targeted specifically to OPCs. These experiments also demonstrate that the cell of mutation may or may not be distinct from the cell of origin in glioma. NSC, neural stem cell; NB, neuroblast; OPC, oligodendrocyte precursor cell; Astro, astrocyte. Cell 2011 146, 187-188DOI: (10.1016/j.cell.2011.06.047) Copyright © 2011 Elsevier Inc. Terms and Conditions