Marie C. Harrisingh, Charles ffrench-Constant Cell Stem Cell

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Presentation transcript:

Can the Irradiated Brain Be Salvaged by Oligodendrocyte Precursor Transplantation? Marie C. Harrisingh, Charles ffrench-Constant Cell Stem Cell Volume 16, Issue 2, Pages 113-114 (February 2015) DOI: 10.1016/j.stem.2015.01.010 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Myelin Damage and the Potential for Repair by Transplanted Human Stem Cell Derived-OPCs Top: in the healthy brain oligodendrocytes myelinate axons (blue). Myelin damage and loss (in green) occurs after radiotherapy or in inflammatory diseases such as multiple sclerosis; whereas in leukodystrophies abnormal or reduced myelination occurs during development. Bottom: radiotherapy causes myelin damage in the brain associated with OPC depletion. Transplanted hESC-derived OPCs (orange) can generate new myelin resulting in functional recovery in rats. (See text for more details.) Cell Stem Cell 2015 16, 113-114DOI: (10.1016/j.stem.2015.01.010) Copyright © 2015 Elsevier Inc. Terms and Conditions