Acute localized exanthematous pustulosis (ALEP) caused by lamotrigine

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Acute localized exanthematous pustulosis (ALEP) caused by lamotrigine Zachary Hopkins, BS, Alice Frigerio, MD, PhD, Jennie T. Clarke, MD JAAD Case Reports Volume 4, Issue 7, Pages 645-647 (August 2018) DOI: 10.1016/j.jdcr.2018.03.017 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, ALEP; initial rash presentation consisted of pustules and vesicles on a base of erythema and edema, predominantly on the right side of the face. B, Punch biopsy from the right cheek showed spongiosis and subcorneal pustules with neutrophils. (Hematoxylin-eosin stain; original magnification: ×200.) The presentation was consistent with ALEP. JAAD Case Reports 2018 4, 645-647DOI: (10.1016/j.jdcr.2018.03.017) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, AGEP; the rash recurred upon rechallenge with lamotrigine. B, Lesions were now widespread and consistent with AGEP. JAAD Case Reports 2018 4, 645-647DOI: (10.1016/j.jdcr.2018.03.017) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions