CD4+ICOS+IL-4+ TFH cells are sparse in human SLOs.

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CD4+ICOS+IL-4+ TFH cells are sparse in human SLOs. CD4+ICOS+IL-4+ TFH cells are sparse in human SLOs. (A) Immunofluorescence staining of CD4 (red), ICOS (green), IL-4 (magenta), and DAPI (blue) in tissues from normal tonsils. The yellow broken line demarcates the area within GCs. The white broken line demarcates the area outside GC. (B) Immunofluorescence staining of CD4 (red), ICOS (green), IL-4 (magenta), and DAPI (blue) in tissues from normal tonsils. (C) Scatter plots depict the mean fluorescence intensity per cell quantified using TissueQuest software for each fluorescent antibody used to stain tissue from an IgG4-RD patient, normal tonsils, and normal mesenteric lymph nodes. (D) CD4+ICOS+IL-4+ (red) and CD4+ICOS+IL-4− (green) cells were quantified in tissue from 12 tonsils. (E) Scatter plots depict the mean fluorescence intensity per cell quantified using TissueQuest software for each fluorescent antibody used to stain normal tonsils and mesenteric lymph nodes. Takashi Maehara et al. LSA 2018;1:e201800050 © 2018 Maehara et al.