Volume 14, Issue 2, Pages (August 2008)

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells Roger R. Gomis, Claudio Alarcón, Cristina Nadal, Catherine.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity Cai-Hong.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

The Kinase-Independent, Second Life of CDK6 in Transcription

We Contain Multitudes: The Protean Face of Retinoblastoma

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Volume 1, Issue 1, Pages (June 2007)

IRS-1: Auditing the effectiveness of mTOR inhibitors

Metastasis gets site specific

Accelerating drug discovery: Open source cancer cell biology?

Boosting Bacterial Metabolism to Combat Antibiotic Resistance

Volume 11, Issue 4, Pages (April 2007)

A Mitochondrial Power Play in Lymphoma

RAS unplugged: Negative feedback and oncogene-induced senescence

Kinase inhibitors: Vice becomes virtue

CALming Down T Cell Acute Leukemia

Killing Tumors by Keeping Ras and PI3′ Kinase Apart

A Sweet New Role for EGFR in Cancer

Annapoorni Rangarajan, Sue J. Hong, Annie Gifford, Robert A. Weinberg

MDS Is a Stem Cell Disorder After All

DAISY: Picking Synthetic Lethals from Cancer Genomes

Volume 26, Issue 1, Pages 1-2 (July 2014)

Volume 13, Issue 1, Pages 1-2 (January 2008)

A Radical Role for p38 MAPK in Tumor Initiation

CALming Down T Cell Acute Leukemia

In This Issue Cell Volume 158, Issue 5, (August 2014)

PICS-ure This: Prosenescence Therapy?

The Case of the Disappearing Drug Target

MicroRNAs and Parallel Stem Cell Lives

Volume 22, Issue 6, Pages (December 2012)

Taru Muranen, Funda Meric-Bernstam, Gordon B. Mills Cancer Cell

Volume 20, Issue 1, Pages 3-5 (July 2011)

The great MYC escape in tumorigenesis

IRS-1: Auditing the effectiveness of mTOR inhibitors

A Mediator Lost in the War on Cancer

The LKB1-AMPK Pathway—Friend or Foe in Cancer?

Andrew J. Holland, Don W. Cleveland Cancer Cell

NOTCH and PI3K-AKT Pathways Intertwined

Volume 14, Issue 4, Pages (October 2008)

Volume 14, Issue 2, Pages (August 2008)

A common pathway for genetic events leading to pheochromocytoma

To Infinium, and Beyond! Cancer Cell

Volume 10, Issue 3, Pages (September 2006)

All Roads Lead to the Ribosome

Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

There's a Time and a Place for MYCN

Ibrutinib Treatment of CLL: The Cancer Fights Back

Pharmacological Rescue of p53 in Cancer Therapy: Widening the Sensitive Tumor Spectrum by Targeting MDMX Jean-Christophe Marine Cancer Cell Volume.

New Myc-anisms for DNA Replication and Tumorigenesis?

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Turning Reciprocal Feedback Regulation into Combination Therapy

Presentation transcript:

Volume 14, Issue 2, Pages 107-108 (August 2008) Drug-Resistant Phosphatidylinositol 3-Kinase: Guidance for the Preemptive Strike Peter K. Vogt Cancer Cell Volume 14, Issue 2, Pages 107-108 (August 2008) DOI: 10.1016/j.ccr.2008.07.008 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Testing for PI3K Inhibitors in Yeast: The “Reverse Halo” Assay The two plates contain a lawn of yeast cells that express p110α and hence fail to grow. A PI3K inhibitor spotted on a cellulose disk (orange) diffuses into the surrounding lawn, inhibits p110α, and restores cell growth (A). A control disk with DMSO has no effect (B). Cancer Cell 2008 14, 107-108DOI: (10.1016/j.ccr.2008.07.008) Copyright © 2008 Elsevier Inc. Terms and Conditions