Figure 2 Therapeutic targeting of the PI3K/AKT/mTOR pathway

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Figure 2 Therapeutic targeting of the PI3K/AKT/mTOR pathway Figure 2 | Therapeutic targeting of the PI3K/AKT/mTOR pathway. Several small-molecule inhibitors targeting different nodes in this pathway are under development for the treatment of cancer. Currently, idelalisib, which selectively targets the PI3Kδ isoform, is the only PI3K inhibitor to be approved by regulatory agencies is idelalisib. Younes, A. et al. (2016) The landscape of new drugs in lymphoma Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2016.205