Platelets and Tumor Cells: A New Form of Border Control

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Platelets and Tumor Cells: A New Form of Border Control Ben Z. Stanger, Mark L. Kahn Cancer Cell Volume 24, Issue 1, Pages 9-11 (July 2013) DOI: 10.1016/j.ccr.2013.06.009 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Tumor Cell Metastasis Is Facilitated by Platelet-Derived ATP Circulating tumor cells associate with and activate blood platelets. Tumor-associated platelets release ATP from their dense granules, which act on endothelial P2Y2 receptors to relax endothelial cell junctions, thereby enabling tumor cells to successfully exit the bloodstream and enter the tissue to form a new metastasis. (Figure courtesy of Dr. Stefan Offermanns and colleagues; reproduced from the online graphical abstract of Schumacher et al., 2013, http://dx.doi.org/10.1016/j.ccr.2013.05.008.) Cancer Cell 2013 24, 9-11DOI: (10.1016/j.ccr.2013.06.009) Copyright © 2013 Elsevier Inc. Terms and Conditions