Patterning Stem Cell Differentiation

Slides:



Advertisements
Similar presentations
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Distinct Self-Renewal and Differentiation Phases in the Niche of Infrequently Dividing Hair Follicle Stem Cells Ying V. Zhang, Janice Cheong, Nichita Ciapurin,
Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr
Bone Marrow-Derived Cell Therapy Stimulates Endogenous Cardiomyocyte Progenitors and Promotes Cardiac Repair Francesco S. Loffredo, Matthew L. Steinhauser,
Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.
Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem
Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.
Wnt1-lmx1a Forms a Novel Autoregulatory Loop and Controls Midbrain Dopaminergic Differentiation Synergistically with the SHH-FoxA2 Pathway Sangmi Chung,
IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.
Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.
Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.
Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.
Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel
Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.
Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey 
Stress Can Be a Good Thing for Blood Formation
Cancer: Inappropriate Expression of Stem Cell Programs?
Back to 2D Culture for Ground State of Intestinal Stem Cells
Kevin G. Chen, Barbara S. Mallon, Ronald D.G. McKay, Pamela G. Robey 
Leigh Turner, Paul Knoepfler  Cell Stem Cell 
Volume 1, Issue 1, Pages (June 2007)
Cell Cycle Rules Pluripotency
The LUNGe to Model Alveolar Lung Diseases in a Dish
Adipocytes at the Core of Bone Function
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
A Path to Insulin Independence: “The End of the Beginning”
Volume 9, Issue 2, Pages (August 2011)
The 3D Genome Shapes Up For Pluripotency
Tamir Rashid, Toshihiro Kobayashi, Hiromitsu Nakauchi  Cell Stem Cell 
Gerry P. Crossan, Juan I. Garaycoechea, Ketan J. Patel  Cell Stem Cell 
Volume 2, Issue 6, Pages (June 2008)
Transplantable Liver Organoids Made from Only Three Ingredients
Justin Brumbaugh, Konrad Hochedlinger  Cell Stem Cell 
Stem Cell Therapies in Clinical Trials: Progress and Challenges
Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture  Dr R.L. Mauck, Ph.D., X. Yuan, Dr.
Why Myc? An Unexpected Ingredient in the Stem Cell Cocktail
Matrix Control of Stem Cell Fate
Tim Willinger, Richard A. Flavell  Cell Stem Cell 
Erin J. Oakley, Gary Van Zant  Cell Stem Cell 
Putting Two Heads Together to Build a Better Brain
Not So Lonely at the Top for Cancer Stem Cells
Location, Location, Location: The Cancer Stem Cell Niche
Puma: Mauling the Intestinal Crypt
A Coated Sponge: Toward Neonatal Brain Repair
Order from Chaos: Single Cell Reprogramming in Two Phases
Transplantable Liver Organoids Made from Only Three Ingredients
Mesenchymal stem cells
Enhanc(er)ing Skin Stem Cells
Cycling toward Elimination of Leukemic Stem Cells
What Your Heart Doth Know
Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors.
Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin
Volume 21, Issue 1, Pages (July 2017)
Aspp1: A Guardian of Hematopoietic Stem Cell Integrity
Powering Reprogramming with Vitamin C
Biomimetic Platforms for Human Stem Cell Research
NO Signals from the Cancer Stem Cell Niche
The Hidden Memory of Differentiating Cells
Waddington’s Valleys and Captain Cook’s Islands
Selfish Stem Cells Compete with Each Other
Chapter 29 - Stem Cells and Generation of New Cells in the
Volume 23, Issue 6, Pages (December 2018)
Volume 163, Issue 2, (October 2015)
Fig. 5. Differentiation assay of fluorescence-activated cell sorter-sorted platelet-derived growth factor receptor beta-positive (PDGFRβ+) cells. (A) In.
Using Notches to Track Mammary Epithelial Cell Homeostasis
Mesp1 at the Heart of Mesoderm Lineage Specification
Mark C. Horowitz, Steven M. Tommasini  Cell Stem Cell 
Justin Brumbaugh, Konrad Hochedlinger  Cell Stem Cell 
Presentation transcript:

Patterning Stem Cell Differentiation Gordana Vunjak-Novakovic  Cell Stem Cell  Volume 3, Issue 4, Pages 362-363 (October 2008) DOI: 10.1016/j.stem.2008.09.007 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Geometry Determines Spatial Patterning of Differentiation Human mesenchymal stem cells were formed into aggregates in the shape of a circle (top row), a square (middle row), or a sinusoidal band (bottom row). After 2 weeks of cultivation in culture medium containing the osteogenic and adipogenic supplements, the cells were stained for alkaline phosphatase (blue) and oil droplets (red). The patterns of cell differentiation mirrored the patterns of shape-generated stress such that the regions of higher stress induced osteogenesis, while the regions of low stress induced adipogenesis. The same logic governed spatial patterning in three-dimensional cell structures. Cell Stem Cell 2008 3, 362-363DOI: (10.1016/j.stem.2008.09.007) Copyright © 2008 Elsevier Inc. Terms and Conditions