Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self- Renewal and Differentiation  Jingting Li, George L. Sen  Journal of Investigative Dermatology  Volume 136, Issue 4, Pages 746-752 (April 2016) DOI: 10.1016/j.jid.2015.12.030 Copyright © 2015 The Authors Terms and Conditions

Figure 1 miRNA- and lncRNA-mediated regulation of epidermal stem and progenitor cell fate. (a) miRNA-mediated regulation of epidermal growth and differentiation. Diagram of miRNA processing, maturation, and subsequent binding to target mRNA. (b) lncRNAs such as ANCR associate with the polycomb repressor EZH2 and promote the silencing of MAF/MAFB at their genomic loci. (c) TINCR promotes epidermal differentiation by associating with Staufen 1 to promote the stabilization of differentiation transcripts such as MAF/MAFB. ANCR, antidifferentiation ncRNA; lncRNA, long noncoding RNA; MAF, V-maf musculoaponeurotic fibrosarcoma oncogene homolog; MAFB, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; miRNA, microRNA; TINCR, terminal differentiation-induced ncRNA. Journal of Investigative Dermatology 2016 136, 746-752DOI: (10.1016/j.jid.2015.12.030) Copyright © 2015 The Authors Terms and Conditions

Figure 2 The exosome and DDX6 complex is necessary for the maintenance of epidermal stem and progenitor cell function. (a) Diagram of the two major mRNA degradation pathways within mammalian cells including the 5′–3′ and 3′–5′ pathways mediated by XRN1 and the exosome complex, respectively. The exosome complex is necessary to prevent premature differentiation of epidermal stem and progenitor cells by targeting and degrading mRNAs that encode for transcription factors that promote differentiation. (b) DDX6 associates with YBX1/EIF4E to promote the translation of self-renewal/proliferation mRNAs and associates with EDC3 to degrade differentiation inducing transcripts to promote epidermal progenitor cell function. EDC3, enhancer of mRNA decapping protein 3. Journal of Investigative Dermatology 2016 136, 746-752DOI: (10.1016/j.jid.2015.12.030) Copyright © 2015 The Authors Terms and Conditions