Antagonizing ClpP: A New Power Play in Targeted Therapy for AML

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Antagonizing ClpP: A New Power Play in Targeted Therapy for AML Karilyn Larkin, John C. Byrd Cancer Cell Volume 27, Issue 6, Pages 747-749 (June 2015) DOI: 10.1016/j.ccell.2015.05.013 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 ClpP’s Proposed Role in Oxidative Phosphorylation (A) ClpP is a nuclear encoded serine protease that is translated in the cytoplasm and then trafficked into the mitochondria, where it is assembled into tetradecamers with its chaperone protein ClpX. (B) Based on protein interaction assays, ClpP associates with members of the electron transport chain, specifically succinate dehydrogenase subunit A (SDHA), and other enzymes inherent to metabolism. Cole et al. (2015) hypothesized that ClpP plays an analogous role to cytosolic proteasomes and degrades dysfunctional proteins within the mitochondria. Cancer Cell 2015 27, 747-749DOI: (10.1016/j.ccell.2015.05.013) Copyright © 2015 Elsevier Inc. Terms and Conditions