A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis Donald Y.M. Leung, MD, PhD, Brett.

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Presentation transcript:

A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis Donald Y.M. Leung, MD, PhD, Brett Jepson, MS, Lisa A. Beck, MD, Jon M. Hanifin, MD, Lynda C. Schneider, MD, Amy S. Paller, MD, Katherine Monti, PhD, Gloria David, PhD, Jennifer Canniff, BS, Margarita Gomez Lorenzo, MD, Adriana Weinberg, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 5, Pages 1575-1582.e8 (May 2017) DOI: 10.1016/j.jaci.2016.12.952 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 CONSORT diagram of study participants. ID, Intradermal; IM, intramuscular. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Day 28 postvaccination influenza B, H1N1, and H3N2 seroprotection and seroconversion by vaccination route, diagnostic group, and S aureus skin colonization. Seroprotection (HAI titers ≥ 1:40) and seroconversion (4-fold or greater increase in HAI titers over baseline titers) percentages and upper 95% CIs are displayed. Pairwise comparisons are performed by using the Fisher exact test. ID, Intradermal; IM, intramuscular; NA, nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Baseline influenza B, H1N1, and H3N2 seroprotection by diagnostic group. Baseline seroprotection is an HAI titer of 1:40 or greater before vaccination. NA, Nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Baseline IgE and IgG specific for SEB and TSST-1 by diagnostic group and S aureus skin colonization. Unadjusted geometric means are displayed for each group. Pairwise comparisons are based on left-censored regression models on the log10 scale. Values of less than the lower limit of detection (0.1) are plotted on the bottom of the panel, if applicable. For IgE, 1 kUA/L = 2.4 μg/L; for IgG, 1 mgA/L = 1 mg/L. NA, Nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Day 28 postvaccination influenza B, H1N1, and H3N2 HAI titer fold increase over baseline by vaccination route, diagnostic group, and S aureus skin colonization status. Unadjusted geometric means are displayed for each group. Pairwise comparisons are based on robust regression models of the log2 HAI titer fold increase. HAI antibody titers of less than 1:10 have been imputed as 1:5, and titers of 1:1280 or greater have been imputed as 1:2560 for analyses prior to calculating the fold increase. ID, Intradermal; IM, intramuscular; NA, nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Day 28 postvaccination influenza B–specific IgG1 and IgG2 levels by vaccination route, diagnostic group, and S aureus skin colonization. Unadjusted geometric means are displayed for each group. Pairwise comparisons are based on robust regression models of the log10 value. Values outside the limits of quantification (IgG1, 10 and 170; IgG2, 24 and 380 for lower and upper limits, respectively) are imputed by using multiple imputation methods and are indicated at the top and bottom of the plots. 10,000 ng/mL = 1 mg/dL. ID, Intradermal; IM, intramuscular; NA, nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 Day 28 postvaccination influenza B–specific IgG3 and IgA levels by vaccination route, diagnostic group, and S aureus skin colonization. Unadjusted geometric means are displayed for each group. Pairwise comparisons are based on robust regression models of the log10 value. Values outside the limits of quantification (IgG3, 6 and 180 for lower and upper limits, respectively; IgA, 3000 for upper limit) are imputed by using multiple imputation methods and are indicated at the top and bottom of the plots. 10,000 ng/mL = 1 mg/dL. ID, Intradermal; IM, intramuscular; NA, nonatopic. Journal of Allergy and Clinical Immunology 2017 139, 1575-1582.e8DOI: (10.1016/j.jaci.2016.12.952) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions