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ANCA disease: immunoserology and pathogenesis Alenka Vizjak Institute of Pathology · Faculty of Medicine University of Ljubljana, Ljubljana, Slovenia.

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ANCA disease: immunoserology and pathogenesis

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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.140 Figure 2 Comparison of the receiver operating characteristics curves for different ANCA assays Figure 2 | Comparison of the receiver operating characteristics curves for different ANCA assays. This graph depicts the receiver operating characteristics (ROC) curves for different methods of anti-neutrophil cytoplasmic antibody (ANCA) detection by indirect immunofluorescence (IIF) and by myeloperoxidase (MPO)-specific and proteinase 3 (PR3)-specific immunoassays. The figure demonstrates the substantial variation between the IIF methods and the good performance of antigen-specific immunoassays. IIF was performed with ethanol-fixed neutrophils using either the manual Copenhagen approach (blue line) or automated Aklides platform (orange line). IIF was also performed with ethanol-fixed neutrophils in combination with additional tests on formalin-fixed neutrophils and HEp-2 cells using either the manual Bad Bramstedt approach (red line) or automated EuroPattern platform (purple line). Immunoassays were performed using a third generation PR3-ANCA and first generation MPO-ANCA enzyme-linked immunosorbent assays (ELISAs) from Euroimmun (green line). This figure was adapted with permission obtained from Csernok, E., et al. Evaluation of automated multi-parametric indirect immunofluorescence assays to detect anti-neutrophil cytoplasmic antibodies (ANCA) in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Autoimmun. Rev. 15, 736–741 (2016). This figure was adapted with permission obtained from Csernok, E., et al. Evaluation of automated multi-parametric indirect immunofluorescence assays to detect anti-neutrophil cytoplasmic antibodies (ANCA) in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Autoimmun. Rev. 15, 736–741 (2016) Bossuyt, X. et al. (2017) Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.140