Increased cyclic guanosine monophosphate levels and continuous-flow left-ventricular assist devices: Implications for gastrointestinal bleeding Liza.

Slides:

Advertisements

Similar presentations

Manuel J. Antunes, MD, PhD, DSc

Advertisements

Aortic valve replacement in low-flow, low-gradient aortic stenosis: Left ventricular ejection fraction matters Victor Dayan, MD, PhD, Philippe Pibarot,

Long-term mechanical circulatory support: A new disease state?

Endoscopic Robotic Mitral Valve Surgery

Acute impact of left ventricular unloading by left ventricular assist device on the right ventricle geometry and function: Effect of nitric oxide inhalation

Martin Strueber, MD, Anna L

Risk of stroke early after implantation of a left ventricular assist device Takaaki Samura, MD, Daisuke Yoshioka, MD, PhD, Koichi Toda, MD, PhD, Ryoto.

The days of future past Neel K. Ranganath, MD, Aubrey C. Galloway, MD

Effects on pre- and posttransplant pulmonary hemodynamics in patients with continuous-flow left ventricular assist devices Ranjit John, MD, Kenneth Liao,

Are preoperative B-type natriuretic peptide levels associated with outcome after pulmonary artery banding and the double switch operation in patients.

N-terminal B-type natriuretic peptide levels in pediatric patients with congestive heart failure undergoing cardiac surgery Rowan Walsh, MD, Clark Boyer,

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Elucidating the intricate mechanisms of gastrointestinal bleeding in a continuous-flow left ventricular assist device will lead to future therapeutic.

Form ever follows function

William M. DeCampli, MD, PhD

Multilevel data analysis: What? Why? How?

Go on-pump or off-pump in diabetic patients?

New treatment approaches create new disease processes: A short guide on how to reduce unexpected events to a minimum Martin Czerny, MD, MBA The Journal.

Resuscitation practices in cardiac surgery

In vitro hemodynamic characterization of HeartMate II at 6000 rpm: Implications for weaning and recovery Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid.

Intra-aortic balloon pump therapy negatively affects flow through a continuous-flow left ventricular assist device Dipanjan Banerjee, MD, MS, Chun Choi,

The lord of the rings Antonio Miceli, MD, PhD

Aldo R. Castañeda, MD, PhD: Recipient of the Lifetime Achievement Award and 74th president of The American Association for Thoracic Surgery Pedro J.

A technique for implanting outflow cannulas for Berlin Heart EXCOR ventricular assist device in small pediatric patients Khanh Nguyen, MD The Journal.

Reduced pleural drainage, length of stay, and readmissions using a modified Fontan management protocol Nancy A. Pike, PhD, Carol A. Okuhara, MN, Joy.

Expanding left ventricular assist device use to patients with disabilities: The role of assistive technology Juan A. Crestanello, MD The Journal of.

Kyle W. Riggs, MD, David L.S. Morales, MD

Intra-aortic balloon pumps and continuous flow left ventricular assist devices: Don't let balloon pumps overstay their welcome Kevin G. Soucy, PhD, Steven.

Long-term outcome of patients on continuous-flow left ventricular assist device support Koji Takeda, MD, PhD, Hiroo Takayama, MD, PhD, Bindu Kalesan,

Adverse events in contemporary continuous-flow left ventricular assist devices: A multi- institutional comparison shows significant differences John M.

Vivek Rao, MD, PhD, Mehmet C. Oz, MD, Margaret A

Left ventricular assist device therapy in a patient with hearing and speech disabilities Sotirios Spiliopoulos, MD, PhD, Vera Hergesell, MD, Otto Dapunt,

It's not “just a shunt” but sometimes it should be…

Do we need a bibliometrician to know which way the wind is blowing?

A first start for lung transplantation?

Right ventricular failure after cardiac surgery: Why can't right ventricular assist device support fix the problem? Francis D. Pagani, MD, PhD The Journal.

William L. Holman, MD, James K. Kirklin, MD, David C

Historical perspectives of The American Association for Thoracic Surgery: Robert M. Janes, MD ( ) Myunghyun Lee, MD, Vivek Rao, MD, PhD The.

Jeevanantham Rajeswaran, PhD, Eugene H. Blackstone, MD

Niv Ad, MD, Lawrence M. Wei, MD

Frank C. Spencer, MD, FACS, pioneering cardiothoracic surgeon

Attachment disorder in thoracoabdominal surgery

The Ross procedure: Time to reevaluate the guidelines

Manuel J. Antunes, MD, PhD, DSc

Video-assisted resection for lung cancer results in fewer complications Lunxu Liu, PhD, MD, FRCS The Journal of Thoracic and Cardiovascular Surgery

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Prognosis and “granularity”: Building on staging foundations?

Left ventricular assist device implantation after acute anterior wall myocardial infarction and cardiogenic shock: A two-center study Nicholas C. Dang,

The origins of open heart surgery at the University of Minnesota 1951 to 1956 Richard A. DeWall, MD The Journal of Thoracic and Cardiovascular Surgery

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

Ventricular assistant in restrictive cardiomyopathy: Making the right connection Robert D.B. Jaquiss, MD The Journal of Thoracic and Cardiovascular Surgery

The continuing challenge of congenital heart disease in China

Reliability of risk algorithms in predicting early and late operative outcomes in high-risk patients undergoing aortic valve replacement Todd M. Dewey,

231 Abnormal Chronotropic Responses And Oxygen Pulse in Long-Term Continuous Flow Left Ventricular Assist Device L. Grosman-Rimon, D. Cherney, L. Tumiati,

Cerebrovascular accidents in patients with a ventricular assist device

Seeing is believing: A call for routine early postoperative hemodynamic transesophageal echocardiography monitoring after left ventricular assist device.

Ralph E. Delius, MD The Journal of Thoracic and Cardiovascular Surgery

Vinay Badhwar, MD, John S. Ikonomidis, MD, PhD, Jeffrey P. Jacobs, MD

“The more things change…”: The challenges ahead

Appropriate Use Criteria for coronary revascularization in patients with stable ischemic heart disease: What the surgeon needs to know Harold L. Lazar,

Proactive or reactive? Best approach to limb ischemia in peripheral venoarterial extracorporeal life support Matthew C. Black, MD, Mark S. Slaughter,

The evolution of cardiothoracic critical care

Gastrointestinal bleeding after left ventricular assist device implantation: It is all about the platelets Juan A. Crestanello, MD The Journal of Thoracic.

Did you like Terminator 3 better than Terminator 2

A good chimney requires a good sweep

How do we follow up our patients

Hari R. Mallidi, MD The Journal of Thoracic and Cardiovascular Surgery

Presentation transcript:

Increased cyclic guanosine monophosphate levels and continuous-flow left-ventricular assist devices: Implications for gastrointestinal bleeding Liza Grosman-Rimon, PhD, Laura C. Tumiati, BSc, Avi Fuks, MD, Ira Jacobs, DrMedSci, Spencer D. Lalonde, HBSc, David Z.I. Cherney, MD, PhD, Vivek Rao, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 1, Pages 219-227 (January 2016) DOI: 10.1016/j.jtcvs.2015.09.015 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The top and bottom borders of the box mark the 75th and 25th percentiles, respectively; whiskers mark the 90th and 10th percentiles. A circle with a cross represents extreme outliers beyond the 90th and 10th percentiles; horizontal red line indicates the median. In patients with heart failure, CF-LVAD recipients, and healthy controls: (A) levels of BNP (pg/mL); (B) levels of cGMP (pmol/mL); and (C) levels of CRP (mg/L). BNP, B-type natriuretic peptide; CF-LVAD, continuous flow left-ventricular assist device; cGMP, cyclic guanosine monophosphate; CRP, C-reactive protein. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 219-227DOI: (10.1016/j.jtcvs.2015.09.015) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, The relationship between cGMP (pmol/mL) and BNP (pg/mL) levels in CF-LVAD recipients (B) The relationship between NO (pmol/mL) and length of continuous LVAD support. NO, Nitric oxide; LVAD, left-ventricular assist device; cGMP, cyclic guanosine monophosphate; BNP, B-type natriuretic peptide. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 219-227DOI: (10.1016/j.jtcvs.2015.09.015) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

In CF-LVAD recipients, cGMP levels were significantly correlated with the levels of BNP. While elevated cGMP levels predicted GI Bleeding events, the levels of BNP did not predict bleeding events in these patients. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 219-227DOI: (10.1016/j.jtcvs.2015.09.015) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions