A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia–associated.

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A heparin-bonded vascular graft generates no systemic effect on markers of hemostasis activation or detectable heparin-induced thrombocytopenia–associated antibodies in humans Jan M.M. Heyligers, MD, PhD, Ton Lisman, PhD, Hence J.M. Verhagen, MD, PhD, Cees Weeterings, Msc, Philip G. de Groot, PhD, Frans L. Moll, MD, PhD Journal of Vascular Surgery Volume 47, Issue 2, Pages 324-329 (February 2008) DOI: 10.1016/j.jvs.2007.10.005 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 Mean levels of markers of coagulation or platelet activation in patients receiving plain expanded polytetrafluoroethylene (ePTFE) or Propaten grafts (W. L. Gore & Associates, Flagstaff, Ariz) at various times after surgery compared with preoperative levels. Error bars indicate standard error of mean. sGPV, soluble glycoprotein V; F1+2, prothrombin fragment 1+2; FPA, fibrinopeptide A; TAT, thrombin-antithrombin complexes. Journal of Vascular Surgery 2008 47, 324-329DOI: (10.1016/j.jvs.2007.10.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 Mean platelet count of patients receiving either a Propaten (W.L. Gore & Associates, Flagstaff, Ariz) or expanded polytetrafluoroethylene (ePTFE) graft at various times before and after surgery. Error bars indicate standard error of mean. Journal of Vascular Surgery 2008 47, 324-329DOI: (10.1016/j.jvs.2007.10.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 Absolute platelet count of a patient who received an expanded polytetrafluoroethylene (ePTFE) graft but was excluded from the analysis because systemic heparin was needed for 4 days postoperatively. A 45% decline in platelet count was observed at day 5, which recovered up to normal levels at week 6; moreover, no heparin/platelet factor 4 complex antibodies developed in this patient. Journal of Vascular Surgery 2008 47, 324-329DOI: (10.1016/j.jvs.2007.10.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions