Shannon D. Sullivan, M. D. , Philip M. Sarrel, M. D. , Lawrence M

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Presentation transcript:

Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause Shannon D. Sullivan, M.D., Philip M. Sarrel, M.D., Lawrence M. Nelson, M.D. Fertility and Sterility Volume 106, Issue 7, Pages 1588-1599 (December 2016) DOI: 10.1016/j.fertnstert.2016.09.046 Copyright © 2016 Terms and Conditions

Figure 1 Percentage change over 3 years in (A) femoral neck and (B) lumbar spine bone mineral density (BMD) in healthy control women and women with 46,XX spontaneous primary ovarian insufficiency treated with E2 +P or E2 + P + T. With permission from Popat et al. (36). Fertility and Sterility 2016 106, 1588-1599DOI: (10.1016/j.fertnstert.2016.09.046) Copyright © 2016 Terms and Conditions

Figure 2 Change in 24-hour (A, C) ambulatory and (B, D) clinic (A, B) systolic (SBP) and (C, D) diastolic (DBP) blood pressure in women with primary ovarian insufficiency treated with the use of physiologic hormone replacement therapy (solid bars) or standard oral contraceptive pills (hatched bars). With permission from Langrish et al. (82). Fertility and Sterility 2016 106, 1588-1599DOI: (10.1016/j.fertnstert.2016.09.046) Copyright © 2016 Terms and Conditions

Figure 3 Changes in (A) serum creatinine, (B) plasma renin activity (PRA), (C) angiotensin II, and (D) aldosterone concentrations in women with primary ovarian insufficiency treated with the use of physiologic hormone replacement therapy (solid bars) or standard oral contraceptive pills (hatched bars). With permission from Langrish et al. (82). Fertility and Sterility 2016 106, 1588-1599DOI: (10.1016/j.fertnstert.2016.09.046) Copyright © 2016 Terms and Conditions