Impact of Pretransplant Therapy and Depth of Disease Response before Autologous Transplantation for Multiple Myeloma Ravi Vij, Shaji Kumar, Mei-Jie Zhang,

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Presentation transcript:

Impact of Pretransplant Therapy and Depth of Disease Response before Autologous Transplantation for Multiple Myeloma Ravi Vij, Shaji Kumar, Mei-Jie Zhang, Xiaobo Zhong, Jiaxing Huang, Angela Dispenzieri, Muneer H. Abidi, Jennifer M. Bird, César O. Freytes, Robert Peter Gale, Tamila L. Kindwall-Keller, Robert A. Kyle, Daniel J. Landsburg, Hillard M. Lazarus, Reinhold Munker, Vivek Roy, Manish Sharma, Dan T. Vogl, Baldeep Wirk, Parameswaran N. Hari Biology of Blood and Marrow Transplantation Volume 21, Issue 2, Pages 335-341 (February 2015) DOI: 10.1016/j.bbmt.2014.10.023 Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) PFS of patients who achieved suboptimal response (<PR) vs. an overall response (CR/PR) to first-line induction chemotherapy. (B) OS of patients who achieved suboptimal response (<PR) vs. an overall response (CR/PR) to first-line induction chemotherapy. Biology of Blood and Marrow Transplantation 2015 21, 335-341DOI: (10.1016/j.bbmt.2014.10.023) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 TRM, REL/progression, PFS, and OS of SALVAGE vs. NO SALVAGE cohorts. Biology of Blood and Marrow Transplantation 2015 21, 335-341DOI: (10.1016/j.bbmt.2014.10.023) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Effect of salvage on survival in patients with non-response to bortezomib/thalidomide/lenalidomide in first-line therapy. Biology of Blood and Marrow Transplantation 2015 21, 335-341DOI: (10.1016/j.bbmt.2014.10.023) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Effect of salvage on survival in patients receiving bortezomib and/or lenalidomide in first-line therapy. Biology of Blood and Marrow Transplantation 2015 21, 335-341DOI: (10.1016/j.bbmt.2014.10.023) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 OS of patients who attained CR/PR after salvage compared with no salvage therapy (A) and compared with no response to salvage (B). Biology of Blood and Marrow Transplantation 2015 21, 335-341DOI: (10.1016/j.bbmt.2014.10.023) Copyright © 2015 American Society for Blood and Marrow Transplantation Terms and Conditions