Expression of acidic fibroblast growth factor in Barrett's esophagus and associated esophageal adenocarcinoma Robert A. Soslow, MD, Liang Ying, BS, Nasser.

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Presentation transcript:

Expression of acidic fibroblast growth factor in Barrett's esophagus and associated esophageal adenocarcinoma Robert A. Soslow, MD, Liang Ying, BS, Nasser K. Altorki, MD The Journal of Thoracic and Cardiovascular Surgery Volume 114, Issue 5, Pages 838-843 (November 1997) DOI: 10.1016/S0022-5223(97)70089-8 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 FGF-1 expression in Barrett's esophagus and esophageal adenocarcinoma. A, Intestinal metaplasia: Metaplastic mucosa, which includes intestinal-type goblet cells, does not express FGF-1. B, Low-grade dysplasia: A subpopulation of dysplastic glands demonstrate very weak (light gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. C, High-grade dysplasia: All the dysplastic glands demonstrate moderate-to-strong (dark gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. D, Adenocarcinoma: This jagged, infiltrating nest of poorly differentiated adenocarcinoma strongly expresses FGF-1. Note the dark-gray cytoplasmic coloration. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 838-843DOI: (10.1016/S0022-5223(97)70089-8) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 FGF-1 expression in Barrett's esophagus and esophageal adenocarcinoma. A, Intestinal metaplasia: Metaplastic mucosa, which includes intestinal-type goblet cells, does not express FGF-1. B, Low-grade dysplasia: A subpopulation of dysplastic glands demonstrate very weak (light gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. C, High-grade dysplasia: All the dysplastic glands demonstrate moderate-to-strong (dark gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. D, Adenocarcinoma: This jagged, infiltrating nest of poorly differentiated adenocarcinoma strongly expresses FGF-1. Note the dark-gray cytoplasmic coloration. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 838-843DOI: (10.1016/S0022-5223(97)70089-8) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 FGF-1 expression in Barrett's esophagus and esophageal adenocarcinoma. A, Intestinal metaplasia: Metaplastic mucosa, which includes intestinal-type goblet cells, does not express FGF-1. B, Low-grade dysplasia: A subpopulation of dysplastic glands demonstrate very weak (light gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. C, High-grade dysplasia: All the dysplastic glands demonstrate moderate-to-strong (dark gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. D, Adenocarcinoma: This jagged, infiltrating nest of poorly differentiated adenocarcinoma strongly expresses FGF-1. Note the dark-gray cytoplasmic coloration. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 838-843DOI: (10.1016/S0022-5223(97)70089-8) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 FGF-1 expression in Barrett's esophagus and esophageal adenocarcinoma. A, Intestinal metaplasia: Metaplastic mucosa, which includes intestinal-type goblet cells, does not express FGF-1. B, Low-grade dysplasia: A subpopulation of dysplastic glands demonstrate very weak (light gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. C, High-grade dysplasia: All the dysplastic glands demonstrate moderate-to-strong (dark gray) cytoplasmic coloration with the FGF-1 monoclonal antibody. D, Adenocarcinoma: This jagged, infiltrating nest of poorly differentiated adenocarcinoma strongly expresses FGF-1. Note the dark-gray cytoplasmic coloration. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 838-843DOI: (10.1016/S0022-5223(97)70089-8) Copyright © 1997 Mosby, Inc. Terms and Conditions