Volume 93, Issue 3, Pages (March 2018)

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Volume 93, Issue 3, Pages 700-705 (March 2018) IgA nephropathy and IgA vasculitis with nephritis have a shared feature involving galactose-deficient IgA1-oriented pathogenesis Hitoshi Suzuki, Junichi Yasutake, Yuko Makita, Yuki Tanbo, Kohei Yamasaki, Tadashi Sofue, Toshiki Kano, Yusuke Suzuki Kidney International Volume 93, Issue 3, Pages 700-705 (March 2018) DOI: 10.1016/j.kint.2017.10.019 Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 1 Glomerular deposition of galactose-deficient IgA1 in patients with IgA nephropathy (IgAN). Double staining with anti-IgA polyclonal antibody and KM55 monoclonal antibody was performed on biopsy specimens from 48 patients with IgAN. Five clinical cases are shown. Galactose-deficient IgA1 was clearly localized predominantly in the mesangium with IgA C3. (Bars = 100 μm; original magnification X200.) To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2018 93, 700-705DOI: (10.1016/j.kint.2017.10.019) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 2 KM55 mAb staining. (a) KM55 mAb staining in various types of glomerular diseases. Glomerular galactose-deficient IgA1 staining was negative in cases of hepatitis C virus–related nephropathy (HCV-RN), hepatic glomerulosclerosis, idiopathic membranous nephropathy (MN), secondary MN, acute poststreptococcal glomerulonephritis (APSGN), antineutrophil cytoplasmic antibody (ANCA)–related nephropathy, and minimal change nephrotic syndrome (MCNS).(b) KM55 mAb staining in lupus nephritis. Five cases of lupus nephritis are shown as examples. In all cases of lupus nephritis that were accompanied by glomerular IgA deposition, glomerular galactose-deficient IgA1 staining was negative. (c) KM55 mAb staining in IgA vasculitis with nephritis (IgA-VN). Five cases of IgA-VN are shown as examples. All cases of IgA-VN exhibited glomerular galactose-deficient IgA1 staining, mainly in the mesangial area, as seen in cases of IgA nephropathy (IgAN). (Bars = 100 μm; original magnification X200.) To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2018 93, 700-705DOI: (10.1016/j.kint.2017.10.019) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 2 KM55 mAb staining. (a) KM55 mAb staining in various types of glomerular diseases. Glomerular galactose-deficient IgA1 staining was negative in cases of hepatitis C virus–related nephropathy (HCV-RN), hepatic glomerulosclerosis, idiopathic membranous nephropathy (MN), secondary MN, acute poststreptococcal glomerulonephritis (APSGN), antineutrophil cytoplasmic antibody (ANCA)–related nephropathy, and minimal change nephrotic syndrome (MCNS).(b) KM55 mAb staining in lupus nephritis. Five cases of lupus nephritis are shown as examples. In all cases of lupus nephritis that were accompanied by glomerular IgA deposition, glomerular galactose-deficient IgA1 staining was negative. (c) KM55 mAb staining in IgA vasculitis with nephritis (IgA-VN). Five cases of IgA-VN are shown as examples. All cases of IgA-VN exhibited glomerular galactose-deficient IgA1 staining, mainly in the mesangial area, as seen in cases of IgA nephropathy (IgAN). (Bars = 100 μm; original magnification X200.) To optimize viewing of this image, please see the online version of this article at www.kidney-international.org. Kidney International 2018 93, 700-705DOI: (10.1016/j.kint.2017.10.019) Copyright © 2017 International Society of Nephrology Terms and Conditions