Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride

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Presentation transcript:

Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride M. Meulyzer, D.V.M., P. Vachon, D.V.M., Ph.D., Dipl. A.C.L.A.M., F. Beaudry, Ph.D., T. Vinardell, D.V.M., H. Richard, G. Beauchamp, Ph.D., S. Laverty, M.V.B., M.R.C.V.S., Dipl. A.C.V.S., Dipl. E.C.V.S. Osteoarthritis and Cartilage Volume 16, Issue 9, Pages 973-979 (September 2008) DOI: 10.1016/j.joca.2008.01.006 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Quantification of glucosamine by Liquid Chromatography Electrospray Tandem Mass Spectrometry (LC-ESI/MS/MS). (A) Chromatogram of a blank sample. (B) Chromatogram of an extracted horse plasma sample with endogenous glucosamine. Osteoarthritis and Cartilage 2008 16, 973-979DOI: (10.1016/j.joca.2008.01.006) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean (±SD) plasma concentrations of glucosamine in horses (n=8) following IV administration of 20mg/kg glucosamine sulphate (A) or glucosamine hydrochloride (B); following NG administration of 20mg/kg glucosamine sulphate (C) or glucosamine hydrochloride (D). Osteoarthritis and Cartilage 2008 16, 973-979DOI: (10.1016/j.joca.2008.01.006) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions