Treatment Decisions in Chemorefractory Follicular Lymphoma

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Presentation transcript:

Treatment Decisions in Chemorefractory Follicular Lymphoma

This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US, and data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

Chemorefractory Follicular Lymphoma

Risk Stratification

Integration of Genetic Mutations Into Risk Stratification (M7-FLIPI)

Prognostic Value of Post-Treatment PET Scan

NCCN Recommended Treatments for Follicular Lymphoma (Grades 1-2)*

Phase 2 Trial of Idelalisib Monotherapy in Relapsed/Refractory FL

Comparison of PFS With Previous Line of Therapy Before Study Inclusion in Patients With Follicular Lymphoma

Phase 2 Idelalisib Monotherapy Adverse Events of Interest

Phase 2 Trial of Ibrutinib Monotherapy in Relapsed/Refractory FL

Lenalidomide Plus Rituximab in Relapsed FL Phase 3 CALGB 50401 Study

Phase 3b MAGNIFY Study Lenalidomide Plus Rituximab in Chemoresistant NHL

Obinutuzumab Plus Bendamustine Phase 3 GADOLIN Study

Radioimmunotherapy

CAR T-Cell Therapy

Personalizing Treatment in the Chemorefractory Population

Planned Intergroup S1608 Phase 2 Trial

Stem Cell Transplant in Patients With Early Chemoimmunotherapy Failure

Rational Treatment Combinations

Future Directions and Unmet Needs

Key Takeaways