IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. IHC analyses.

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IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. Stained sections are from adenocarcinomas in the different diet groups at 6 months of age. Representative images from mice in the 30% CR diet group (left column) show in situ adenocarcinomas, and representative images from mice in overweight control and DIO diet groups show a mix of in situ and invasive adenocarcinomas. Staining is shown for phosphorylated Akt (Ser473), mTOR (Ser2448), S6 ribosomal protein (Ser235/236), and STAT3 (Tyr705). Also shown is staining for the proliferation-associated markers Ki67 and cyclin D1. Jorge Blando et al. Cancer Prev Res 2011;4:2002-2014 ©2011 by American Association for Cancer Research