Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche

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Presentation transcript:

Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche Julia P. Andreotti, Luiza Lousado, Luiz Alexandre V. Magno, Alexander Birbrair Cell Stem Cell Volume 21, Issue 3, Pages 293-294 (September 2017) DOI: 10.1016/j.stem.2017.08.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 POMC-Expressing Neurons are a Key Component of the SVZ NSC Niche The NSC niche is a specialized microenvironment that supports NSCs and provides them with behavioral cues. Paul et al. show that POMC+ neurons projecting from the hypothalamus are a key component of the anterior ventral portion of the SVZ NSC niche. Physiological manipulation of these POMC+ neurons via feeding and fasting leads to activation of a subset of NSCs and a consequent increase in production of a specific subtype of interneuron within the olfactory bulb. Cell Stem Cell 2017 21, 293-294DOI: (10.1016/j.stem.2017.08.005) Copyright © 2017 Elsevier Inc. Terms and Conditions