Ping Yang, M. D. , Xin Luan, M. D. , Yingqian Peng, M. D

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Novel zona pellucida gene variants identified in patients with oocyte anomalies Ping Yang, M.D., Xin Luan, M.D., Yingqian Peng, M.D., Tailai Chen, M.D., Ph.D., Shizhen Su, M.S., Changming Zhang, B.S., Zhao Wang, B.S., Lei Cheng, B.S., Xin Zhang, B.S., Ying Wang, B.S., Zi-Jiang Chen, M.D., Ph.D., Han Zhao, M.D., Ph.D. Fertility and Sterility Volume 107, Issue 6, Pages 1364-1369 (June 2017) DOI: 10.1016/j.fertnstert.2017.03.029 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Four novel variants detected in cases of oocyte morphologic defects. (A) Two variants (c.247T>C and c.1413G>A) in the zona pellucida 1 (ZP1) gene. (B) Two variants (c.1599G>T and c.1696T>C) in the zona pellucida 2 (ZP2) gene. The top parts show the schematic diagram of (A) ZP1 and (B) ZP2, respectively. The bottom parts indicate the variant amino acids involved are conserved among different species by protein sequence alignment. Fertility and Sterility 2017 107, 1364-1369DOI: (10.1016/j.fertnstert.2017.03.029) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions