Figure 1 Towards precision PRRT for neuroendocrine tumours

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Figure 1 Towards precision PRRT for neuroendocrine tumours Figure 1 | Towards precision PRRT for neuroendocrine tumours. Liquid biopsies could help tailor peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumours. The schematic shows tumour cell response to 177Lu-Octreotate therapy. Tumours (blue) that exhibit a circulating gastroenteropancreatic gene fingerprint with intact, regulated growth factor signalling pathways and well-differentiated metabolic pathways are responsive to PRRT and undergo substantial DNA damage and tumour apoptosis. Tumours (orange) that are autonomous of growth factor modulation and highly metabolically active (+++) exhibit variable responses to PRRT. ctRNA, circulating tumour RNA. Kidd, M. & Modlin, I. M. (2017) The role of liquid biopsies to manage and predict PRRT for NETs Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.26