Sox2: Masterminding the Root of Cancer

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Sox2: Masterminding the Root of Cancer Wai Leong Tam, Huck Hui Ng Cancer Cell Volume 26, Issue 1, Pages 3-5 (July 2014) DOI: 10.1016/j.ccr.2014.06.024 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Sox2 Expression Underlies Cancer Stem Cell Function In two distinct mouse cancer models, Sox2+ cells initiate tumor growth and spawn differentiated cell lineages that recapitulate primary tumor composition. In medulloblastoma, Sox2+ cells are quiescent and, in lineage tracing experiments, found to be chemotherapy-resistant, thus promoting tumor recurrence. Conditional deletion of Sox2 from the epidermis in squamous cell carcinoma triggers tumor regression, and Sox2+ cells are responsible for tumor initiation and growth. Tumor propagation by the founder cells appears to recapitulate embryonic and stem cell differentiation programs that operate within normal tissues. Cancer Cell 2014 26, 3-5DOI: (10.1016/j.ccr.2014.06.024) Copyright © 2014 Elsevier Inc. Terms and Conditions