A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size David A. Sidloff,

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Presentation transcript:

A systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size David A. Sidloff, BSc (Hons), MBBS, MRCS, Philip W. Stather, MBChB, MRCS, Edward Choke, MBBS, FRCS, PhD, Matthew J. Bown, MBBCh, MD, FRCS, PGCert (Bioinformatics), Robert D. Sayers, MBChB (Hons), FRCS (Ed), FRCS (Eng), MD Journal of Vascular Surgery Volume 59, Issue 2, Pages 528-535.e4 (February 2014) DOI: 10.1016/j.jvs.2013.10.088 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) diagram of the review. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Forest plot compares mean plasma concentration of fibrinogen between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Forest plot compares mean plasma concentration of D-dimer between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 Meta-regression demonstrates the association between abdominal aortic aneurysm (AAA) diameter and D-dimer concentration. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 5 Forest plot compares mean plasma concentration of tissue plasminogen activator (tPA) between studies. A fixed-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 6 Forest plot compares mean plasma concentration of thrombin-antithrombin III complex (TAT) between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 7 Forest plot compares mean plasma concentration of prothrombin fragments F1+F2 between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 8 Forest plot compares mean plasma concentration of platelet count between studies. A random-effects model was used for meta-analysis. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 1 (online only) a, Funnel plot of studies included for meta-analysis of fibrinogen. b, Funnel plot of studies included for meta-analysis of D-dimer. c, Funnel plot of studies included for meta-analysis of tissue plasminogen activator. d, Funnel plot of studies included for meta-analysis of thrombin-antithrombin III complex (TAT). e, Funnel plot of studies included for meta-analysis of prothrombin fragments F1+F2. f, Funnel plot of studies included for meta-analysis of platelet count. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 2 (online only) Sensitivity analysis: Fibrinogen. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 3 (online only) Sensitivity analysis: D-dimer. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 4 (online only) Sensitivity analysis: Thrombin-antithrombin III complex (TAT). AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Supplementary Fig 5 (online only) Sensitivity analysis: Platelet count. AAA, Abdominal aortic aneurysm; CI, confidence interval; SD, standard deviation. Journal of Vascular Surgery 2014 59, 528-535.e4DOI: (10.1016/j.jvs.2013.10.088) Copyright © 2014 Society for Vascular Surgery Terms and Conditions