Memory: The Incomplete Unhappening of Differentiation

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Presentation transcript:

Memory: The Incomplete Unhappening of Differentiation André Ballesteros-Tato, Troy D. Randall Immunity Volume 35, Issue 4, Pages 496-498 (October 2011) DOI: 10.1016/j.immuni.2011.10.001 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Opposite T Cell:DC and T Cell:B Cell Interactions Promote Tem and Tcm Cell Differentiation After encounter with antigen-bearing DCs, naive CD4+ T cells activate and undergo expansion. Sustained interaction of T cells with DCs leads to IL-2 and IL-12-dependent T-bet upregulation and subsequent terminal Th1 cell differentiation. Sustained interaction of T cells with B cells upregulates Bcl6 and represses T-bet, which favors Tfh and Tcm cell development. After pathogen clearance, a fraction of Th1 and Tcm cells survives the contraction phase and become long-lived Tem and Tcm cells. Immunity 2011 35, 496-498DOI: (10.1016/j.immuni.2011.10.001) Copyright © 2011 Elsevier Inc. Terms and Conditions