Evolution of extended-spectrum β-lactamases by mutation

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Laboratory diagnosis and biosafety issues of biological warfare agents

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Molecular evolution of Mycobacterium tuberculosis

L. Boyanova Clinical Microbiology and Infection

R. Cantón, A. Novais, A. Valverde, E. Machado, L. Peixe, F. Baquero, T

Defining an extended-spectrum β-lactamase

Gut bacterial microbiota and obesity

Approach to diagnosis of infective endocarditis

Anthrax, tularemia, plague, ebola or smallpox as agents of bioterrorism: recognition in the emergency room B.A. Cunha Clinical Microbiology and Infection

Herpes zoster in non-hospitalized children

Migrant health—a cause for concern?

Defining an extended-spectrum β-lactamase

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Gastroenteritis outbreak caused by norovirus associated with the children's club of a hotel located in Majorca, Spain A. Doménech-Sánchez Clinical Microbiology.

J.-P. Van geertruyden Clinical Microbiology and Infection

R. Cantón Clinical Microbiology and Infection

Genital Chlamydia trachomatis infections

Louis Pasteur, from crystals of life to vaccination

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Surveillance of Legionnaires’ disease in Austria

How to evaluate and predict the epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach D. Guillemot Clinical Microbiology.

Structure of grepafloxacin relative to activity and safety profile

Vector control: a cornerstone in the malaria elimination campaign

P.C. Appelbaum Clinical Microbiology and Infection

J.P. Donnelly, B.E. De Pauw Clinical Microbiology and Infection

New Delhi metallo-beta-lactamase (NDM-1): towards a new pandemia?

Training for the infectious diseases speciality in Norway

B. Gordts Clinical Microbiology and Infection

Laboratory diagnosis and biosafety issues of biological warfare agents

CMI editorial report 2011 Clinical Microbiology and Infection

Bacterial resistance—the clinical challenge

Control of infections due to extended-spectrum β-lactamase-producing organisms in hospitals and the community R.E. Warren, G. Harvey, R. Carr, D. Ward,

Elements of design: the knowledge on which we build

Four-year epidemiological study of extended-spectrum β-lactamase-producing Enterobacteriaceae in a French teaching hospital L. Gibold, F. Robin, R.-N.

Levofloxacin in the treatment of ventilator-associated pneumonia

G. Pappas Clinical Microbiology and Infection

Metagenomics and probiotics

Laboratory diagnosis of Clostridium difficile disease

The practice of travel medicine in Europe

T.M. File Clinical Microbiology and Infection

Long-term study of the frequency of Escherichia coli and Klebsiella pneumoniae isolates producing extended-spectrum β-lactamases L. Romero, L. López,

Antibacterial drug discovery in the 21st century

Abstracts cont. Clinical Microbiology and Infection

Pandemic lineages of extraintestinal pathogenic Escherichia coli

A.W. Karchmer Clinical Microbiology and Infection

P.M. Hawkey Clinical Microbiology and Infection

Training in infectious diseases and tropical medicine in Britain

Current experience in treating invasive zygomycosis with posaconazole

Reducing antibiotic use in influenza: challenges and rewards

Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida

Antimicrobial drug development – the past, the present, and the future

R. Cantón, A. Novais, A. Valverde, E. Machado, L. Peixe, F. Baquero, T

Statin use and clinical outcomes among pneumonia patients

Clinical Microbiology and Infection

Listeriosis: a resurgent foodborne infection

K. Kaier, N.T. Mutters, U. Frank Clinical Microbiology and Infection

The atypical pneumonias: clinical diagnosis and importance

Abstracts Clinical Microbiology and Infection

Virology: a scientific discipline facing new challenges

Modelling during an emergency: the 2009 H1N1 influenza pandemic

New oral cephalosporins in pediatric community-acquired infections

B.A. Cunha Clinical Microbiology and Infection

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

Joshua P. Metlay, Daniel E. Singer Clinical Microbiology and Infection

Impact of antibiotic restrictions: the patient's perspective

Comparative study of pediculicidal effect of medical plants

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Evolution of extended-spectrum β-lactamases by mutation M. Gniadkowski Clinical Microbiology and Infection Volume 14, Pages 11-32 (January 2008) DOI: 10.1111/j.1469-0691.2007.01854.x Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Tertiary structure of a class A β-lactamase with positions important for activity indicated. Reproduced with permission from Matagne et al., Biochem J 1998; 330: 581–598. © the Biochemical Society. Clinical Microbiology and Infection 2008 14, 11-32DOI: (10.1111/j.1469-0691.2007.01854.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 2 Possible pathways of evolution of TEM-type extended-spectrum β-lactamases in Poland. Reproduced with permission from Baraniak et al., Antimicrob Agents Chemother 2005; 49: 1872–1880. © American Society for Microbiology. Clinical Microbiology and Infection 2008 14, 11-32DOI: (10.1111/j.1469-0691.2007.01854.x) Copyright © 2008 European Society of Clinical Infectious Diseases Terms and Conditions