Focus on lymphomas Cancer Cell

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Focus on lymphomas Cancer Cell Louis M. Staudt, Wyndham H. Wilson Cancer Cell Volume 2, Issue 5, Pages 363-366 (November 2002) DOI: 10.1016/S1535-6108(02)00178-2

Figure 1 Pathogenetic mechanisms in lymphomas Arrows indicate presumptive target genes and pathways affected by oncogenic events in various lymphoma types. An enhanced version of this figure with references is available as Supplemental Figure S1 at http://www.cancercell.org/cgi/content/full/2/5/363/DC1. Abbreviations: BL, Burkitt's lymphoma; DLBCL, diffuse large B cell lymphoma; ABC, activated B cell; MCL, mantle cell lymphoma; B-NHL, B cell non-Hodgkin's lymphoma; LPCL, lymphoplasmacytoid lymphoma; FL, follicular lymphoma, GCB, germinal center B cell; SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia; CTCL, cutaneous T cell lymphoma; MZL, marginal zone lymphoma; HD, Hodgkin's disease; EBV, Epstein-Barr virus; PTLD, posttransplant lymphoproliferative disorder; ATL, adult T cell lymphoma; ALCL, anaplastic large cell lymphoma. Cancer Cell 2002 2, 363-366DOI: (10.1016/S1535-6108(02)00178-2)

Figure 2 Molecular diagnosis of diffuse large B cell lymphoma (DLBCL) A: Subgroups of DLBCL defined by hierarchical clustering of gene expression data have distinct clinical and pathogenetic features (Davis et al., 2001; Rosenwald et al., 2002). Relative gene expression is depicted on a color scale in which red represents higher expression, green represents lower expression, and black represents median expression. Each column represents a different lymphoma biopsy sample, and each row a different gene. B: A gene expression-based outcome predictor of survival following chemotherapy for DLBCL based on four gene expression signatures (see text for details) and the expression of a single gene, BMP6 (Rosenwald et al., 2002). High expression of a predictor component in a DLBCL tumor correlated with favorable or poor survival as indicated. Patients with DLBCL were assigned an outcome predictor score based on these 5 gene expression variables. The patients were ranked according to their outcome predictor scores and divided into 4 quartiles that are represented by different colors in the Kaplan-Meier plot of overall survival. Cancer Cell 2002 2, 363-366DOI: (10.1016/S1535-6108(02)00178-2)