RNase E Finds Some sRNAs Stimulating

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RNase E Finds Some sRNAs Stimulating Nicholas De Lay, Susan Gottesman Molecular Cell Volume 47, Issue 6, Pages 825-826 (September 2012) DOI: 10.1016/j.molcel.2012.09.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 RNase E-Facilitated Negative Regulation of Gene Expression by sRNAs (A) Pairing of the sRNA to a region around the Shine-Dalgarno site (SD) blocks ribosome binding, allowing degradation of the mRNA; the sRNA is degraded as well. (B) The 5′-monophosphorylated sRNA pairs with the target mRNA; binding of the sRNA 5′ monophophate to RNase E stimulates cleavage of the mRNA by RNase E. The sRNA subsequently disassociates and is able to pair with an additional target mRNA before being degraded. Molecular Cell 2012 47, 825-826DOI: (10.1016/j.molcel.2012.09.007) Copyright © 2012 Elsevier Inc. Terms and Conditions