The 3D Genome Shapes Up For Pluripotency

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The 3D Genome Shapes Up For Pluripotency Tom Sexton, Giacomo Cavalli Cell Stem Cell Volume 13, Issue 1, Pages 3-4 (July 2013) DOI: 10.1016/j.stem.2013.06.013 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Model for the Role of Chromatin Interactions in Mediating Pluripotency Overexpressed Yamanaka transcription factors (blue ovals) bind to motifs at the promoters and enhancers of pluripotency genes (purple rectangles) in differentiated tissues (left panel), but very few are reprogrammed to iPSCs. Chance chromatin interactions between enhancers and promoters, and between pluripotency genes, seem to be required for reprogramming (right panel), and are reinforced by further recruitment of the “architectural proteins” Mediator (yellow squares) and cohesin rings (orange circles), providing a permissive environment for transcriptional activation of the pluripotency genes. Cell Stem Cell 2013 13, 3-4DOI: (10.1016/j.stem.2013.06.013) Copyright © 2013 Elsevier Inc. Terms and Conditions