Positron Emission Tomography in Lung Cancer

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Positron Emission Tomography in Lung Cancer Val J Lowe, MD, Keith S Naunheim, MD The Annals of Thoracic Surgery Volume 65, Issue 6, Pages 1821-1829 (June 1998) DOI: 10.1016/S0003-4975(98)00106-4

Fig 1 Glucose and [18F]fluorodeoxyglucose (18FDG) are transported into the cell in a similar fashion. After FDG phosphorylation, FDG-6-PO4 does not proceed down cellular metabolic pathways, and only minimal amounts leave the cell. The Annals of Thoracic Surgery 1998 65, 1821-1829DOI: (10.1016/S0003-4975(98)00106-4)

Fig 2 (A) Pulmonary nodule (broken arrow) in left anterior lung on computed tomography is hypermetabolic on (B) [18F]fluorodeoxyglucose positron emission tomography (solid arrow). A biopsy sample from the nodule was positive for adenocarcinoma. The Annals of Thoracic Surgery 1998 65, 1821-1829DOI: (10.1016/S0003-4975(98)00106-4)

Fig 3 (A) A 53-year-old man had a large left lung mass (large cell undifferentiated tumor) with associated left hilar adenopathy (arrow) on computed tomography. (B) It also demonstrated a 1.8-cm nonspecific left adrenal mass (arrow). (C) Coronal positron emission tomography showed hypermetabolism indicative of tumor in the left lung mass and left hilar nodes as well as right tracheobronchial nodal (broken arrow), left pleural, and left adrenal (solid arrow) disease. Right-sided adrenal disease is also likely present as seen on position emission tomography, although the right adrenal gland was not enlarged on computed tomography. The Annals of Thoracic Surgery 1998 65, 1821-1829DOI: (10.1016/S0003-4975(98)00106-4)

Fig 4 A 52-year-old man had a history of right upper lobe lung cancer. (A) The chest radiograph showed an ill-defined right hilar opacity and right paratracheal fullness. (B) Coronal positron emission tomography demonstrated right hilar (arrow) and right paratracheal hypermetabolism indicative of recurrent tumor. The Annals of Thoracic Surgery 1998 65, 1821-1829DOI: (10.1016/S0003-4975(98)00106-4)

Fig 5 Transaxial 18F-fluorodeoxyglucose positron emission tomography (PET) image from patient with a history of left lung cancer seen with a new left pleural effusion demonstrating multiple focal areas of hypermetabolism involving the left pleural surface (arrow). The PET metabolic image (bright white) is superimposed on a PET soft-tissue density image or attenuation scan (seen as light gray), also routinely obtained for PET imaging, that shows increased density (pleural fluid) in left lung region. The biopsy specimen documented recurrent tumor in this pleural region. The Annals of Thoracic Surgery 1998 65, 1821-1829DOI: (10.1016/S0003-4975(98)00106-4)