Genetic Modifiers of the Breast Tumor Microenvironment Michael J. Flister, Carmen Bergom  Trends in Cancer  Volume 4, Issue 6, Pages 429-444 (June 2018) DOI: 10.1016/j.trecan.2018.04.003 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Key Figure: Schematic of Host Tumor Microenvironment (TME) Modifier Candidates Multiple nonmalignant cell types in the TME impact breast cancer risk and progression, yet the underlying heritable mechanisms that alter TME cell function and influence breast cancer risk and outcome are frequently overlooked and largely unknown. Depicted here are polymorphic genes from established human breast cancer risk loci that likely function as host TME modifiers of breast cancer. ECM, Extracellular matrix. Trends in Cancer 2018 4, 429-444DOI: (10.1016/j.trecan.2018.04.003) Copyright © 2018 The Authors Terms and Conditions