A Frontline Clinician's Guide to Managing Opioid-Induced Constipation

This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US.

Introduction

Annual Opioid Prescribing Rates: 2006-2016

Opioids Are Associated With Many Common AEs

Opioid-Induced Constipation

What Is OIC?

Pathogenesis of OIC

Working Definitions for OIC

Assessment and Diagnosis: Tools for Stools

Opioid-Related Constipation

Overlapping Nature of Constipation

Standard Treatment Protocols: Constipation

Differentiating OIC From OEC

Case 1: 78-Year-Old Maria

Case 2: 45-Year-Old Jennifer

Bristol Stool Chart

BFI

Who Is Responsible for Managing OIC?

Patient-Provider(s) Partnership for OIC Management

Management Strategies

Case 1 Reminder: Maria (Aged 78 Years)

Case 1: Management for Maria (Aged 78 Years)

Commonly Used Laxatives to Treat Constipation

Currently Approved Therapies

Currently Approved Therapies (cont)

Case 2 Reminder: Jennifer (Aged 45 Years)

Case 2: Management for Jennifer (Aged 45 Years)

Proposed Treatment Algorithm: OEC Based on Responsiveness to Initial Therapy

Proposed Real-World Treatment Algorithm: Opioid Constipation-Naive to Therapy

Key Messages

Abbreviations

Abbreviations (cont)