Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations Tae Jung Kim, MD, PhD, Choon-Taek.

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Radiologic Characteristics of Surgically Resected Non-Small Cell Lung Cancer With ALK Rearrangement or EGFR Mutations Tae Jung Kim, MD, PhD, Choon-Taek Lee, MD, PhD, Sang Hoon Jheon, MD, PhD, Jeong-Soo Park, PhD, Jin-Haeng Chung, MD, PhD The Annals of Thoracic Surgery Volume 101, Issue 2, Pages 473-480 (February 2016) DOI: 10.1016/j.athoracsur.2015.07.062 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Computed tomographic (CT) images of a 45-year-old man with anaplastic lymphoma kinase-positive lung adenocarcinoma. (A) CT scan shows a large solid mass (arrow) with lobulated margin and hypoattenuation with mean attenuation value of 46 Hounsfield units. (B) Lung window image shows ill-defined lesion borders and ground-glass opacity (arrow) at periphery of the tumor. The Annals of Thoracic Surgery 2016 101, 473-480DOI: (10.1016/j.athoracsur.2015.07.062) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Computed tomographic (CT) images of a 35-year-old man with anaplastic lymphoma kinase-positive lung adenocarcinoma. CT scan shows a solid mass with lobulated margin (arrowheads) and hypoattenuation with mean attenuation value of 44 Hounsfield units. Multiple mediastinal and hilar lymphadenopathies are also noted (arrow). The Annals of Thoracic Surgery 2016 101, 473-480DOI: (10.1016/j.athoracsur.2015.07.062) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Computed tomographic (CT) images of (A and B) adenocarcinoma with epidermal growth factor receptor mutation in a 72-year-old women and (C and D) wild-type/wild-type adenocarcinoma in a 70-year-old man. (A) CT scan shows an irregular mass (arrows) with hyperattenuation with mean attenuation value of 85 Hounsfield units (HU). (B) Lung window image shows a large area of ground-glass opacity (arrowheads) surrounding the solid mass. (C and D) CT images show a solid enhancing nodule (arrow) with mean attenuation value of 75 HU. The Annals of Thoracic Surgery 2016 101, 473-480DOI: (10.1016/j.athoracsur.2015.07.062) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Kaplan-Meier curves for overall survival of patients with anaplastic lymphoma kinase (ALK) rearrangement, epidermal growth factor receptor (EGFR) mutation, and wild-type/wild-type (WT/WT) tumors. The median overall survival was significantly longer in ALK-positive patients (37 months) than in patients with EGFR mutation (27 months) and patients with WT/WT tumors (22 months) (p = 0.0266 and p = 0.0007, respectively). The Annals of Thoracic Surgery 2016 101, 473-480DOI: (10.1016/j.athoracsur.2015.07.062) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Graph shows area under the receiver operating characteristic curve (AUC) for discrimination of patients with anaplastic lymphoma kinase rearrangement from those with epidermal growth factor receptor mutation and wild-type/wild-type WT/WT tumor with computed tomographic and clinical findings. The Annals of Thoracic Surgery 2016 101, 473-480DOI: (10.1016/j.athoracsur.2015.07.062) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions