Primary Central Nervous System Lymphoma

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Presentation transcript:

Primary Central Nervous System Lymphoma BRIAN P. O'NEILL, M.D. Mayo Clinic Proceedings Volume 64, Issue 8, Pages 1005-1020 (August 1989) DOI: 10.1016/S0025-6196(12)61228-2 Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Coronal section from 64-year-old man with primary central nervous system lymphoma. Note bulky basal ganglia tumor (large arrow) and second smaller tumor in corpus callosum (small arrow). Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Perivascular accumulation (arrow) of neoplastic lymphocytes and infiltration of surrounding brain. (Hematoxylin-eosin; ×100.) Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Perivascular infiltration with reticulum production in cerebral lymphoma. (Reticulum stain; ×100.) Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Computed tomographic scans of large frontal lobe primary central nervous system lymphoma. A, Without contrast medium, demonstrating increased noncontrasted density. B, After administration of contrast agent, showing dense homogeneous, avid enhancement. Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 Computed tomographic scans of primary central nervous system lymphoma at foramen of Munro. A, At time of initial examination (open arrow). B, After 1 week of corticosteroid treatment, note so-called ghost tumor (closed arrow). Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 6 Periventricular primary central nervous system lymphoma, depicted better on computed tomographic scan (A) than on magnetic resonance image (B, arrow). (See text for further discussion.) Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 7 Graph showing survival time in 188 cases from the literature and 10 additional cases of primary central nervous system lymphoma treated with whole-brain irradiation. Solid line = patients receiving a dosage of 50 Gy or more. Broken line = patients receiving a dosage of less than 50 Gy. The difference was statistically significant (P<0.05). (From Murray and associates.22 By permission of the American Association of Neurological Surgeons.) Mayo Clinic Proceedings 1989 64, 1005-1020DOI: (10.1016/S0025-6196(12)61228-2) Copyright © 1989 Mayo Foundation for Medical Education and Research Terms and Conditions