Ibrain Application CT Brain Perfusion

Slides:

Advertisements

Similar presentations

Y. Duan et al. European Journal of Radiology (2011) Changes in cerebral hemodynamics after carotid stenting of symptomatic carotid artery.

Advertisements

ENV 2006 CS4.1 Envisioning Information: Case Study 4 Focus and Context for Volume Visualization.

Joint Detection-Estimation of Brain Activity in fMRI using Graph Cuts Thesis for the Master degree in Biomedical Engineering Lisbon, 30 th October 2008.

Mina Emad Azmy Research Assistant – Signal and Image Processing Lab.

Dr R. Anjan Bharathi. 3 rd leading cause of mortality & morbidity. Goal of imaging Early and accurate diagnosis Information about the intracranial vasculature.

STIR – 1 Digital Phantom Project

Advances in Emergency Brain Imaging Andrew W. Asimos, MD Director of Emergency Stroke Care Carolinas Medical Center Charlotte, NC.

Role of CT in Acute Stroke Dr. PG Sridhar Sr. Consultant.

FMRI: Biological Basis and Experiment Design Lecture 15: CBF and Localization II CBF techniques Big veins and big voxels 1 light year = 5,913,000,000,000.

1 Bayesian analysis of dynamic MR breast images P. Barone, F. de Pasquale, G. Sebastiani Istituto per le Applicazioni del Calcolo ‘‘M. Picone’’ CNR, Rome.

Validation of Blood Flow Simulations in Intracranial Aneurysms Yue Yu Brown University Final-Project Presentation (Registration)‏

PHYSICS IN NUCLEAR MEDICINE: QUANTITAITVE SPECT AND CLINICAL APPLICATIONS Kathy Willowson Department of Nuclear Medicine, Royal North Shore Hospital University.

The UNIVERSITY of NORTH CAROLINA at CHAPEL HILL Adaptive Weighted Deconvolution Model to Estimate the Cerebral Blood Flow Function in Dynamic Susceptibility.

IIIT Hyderabad Stroke Detection and Segmentation Presented by: Shashank Mujumdar.

M. Reddy, A. Livorine, R. Naini, H. Sucharew, A. Vagal

Diploma Thesis Image-Based Verification of Parametric Models in Heart-Ventricle Volumetry Martin Urschler Institut für Maschinelles Sehen u. Darstellen.

Dr Kneale Metcalf Stroke Physician (NNUHFT)

FROM CONTROL SOFTWARE TO CONTROL SYSTEMS Wojciech Kurek.

THE CORRELATIONS OF 3D PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING AND DYNAMIC SUSCEPTIBILITY CONTRAST PERFUSION MRI IN BRAIN TUMORS Delgerdalai Khashbat,

QUANTITATIVE MRI OF GLIOBLASTOMA RESPONSE Bruce Rosen, MD, PhD Athinoula A. Martinos Center for Biomedical Imaging, MGH. Future Plans/Upcoming Trials Reproducibility.

Developing a Statistical Method of Quantifying Vascular Response after Radiotherapy Michal Stankiewicz Medical Biophysics 3970Z Western University March.

DIFFUSION & PERFUSION MRI IMAGING Dr. Mohamed El Safwany, MD.

Ischemic stroke detection through image processing techniques Allan Felipe Fattori Alves 1.

HighlY Constrained Back PRojection (HYPR) Thank you to Oliver Wieben!!

Andrew W. Asimos, MD How Can We Use Advanced Neuroimaging in the ED to Optimize Treatment Options for Acute Stroke Patients?

Quantitative Estimation of Blood Velocity in T2* Susceptibility Contrast Imaging N.A.Thacker, M.L.J.Scott, M.Pokric, A.Jackson. University of Manchester,

Perfusion MRI in GSK Study

RECPAD - 14ª Conferência Portuguesa de Reconhecimento de Padrões, Aveiro, 23 de Outubro de 2009 David Afonso and João Sanches.

Abstract  Arterial Spin Labeling (ASL) is a noninvasive method for quantifying Cerebral Blood Flow (CBF).  The most common approach is to alternate between.

Azienda Ospedaliero-Universitaria, Arcispedale S. Anna,

before thrombolysis in acute stroke

Kamran M 1, Deuerling-Zheng 2, Mueller-Allissat B 2, Grunwald IQ 1, Byrne JV 1 1. Oxford Neurovascular and Neuroradiology Research Unit, University of.

Certainty of Stroke Diagnosis: Incremental Benefit with CT Perfusion over NC-CT & CTA Richard I. Aviv, Julia Hopyan, Anthony Ciarallo, et al (including.

QIBA DCE-MRI Analysis Algorithm Validation Specification and Testing Daniel Barboriak M.D. Duke University Medical Center

New ways of imaging Stroke/TIA Dr Suzanne O’Leary Neuroradiology SpR Frenchay Hospital.

Biomarkers from Dynamic Images – Approaches and Challenges

Segmentation of 3D microPET Images of the Rat Brain by Hybrid GMM and KDE Tai-Been Chen Department of Medical Imaging and Radiological Science,

Basics of Perfusion Imaging With Dynamic Contrast MRI Larry Panych, PhD Brigham and Women’s Hospital.

Enabling Grids for E-sciencE LRMN ThIS on the Grid Sorina CAMARASU.

Acute Stroke Management

Fractional Flow in Cerebrovascular Disorders

Clinical Audit of Head CT in Stroke Alert Cases: Role of Radiology Resident and CT Technologist Awareness in improving Head CT reporting time K Hooda,

Timing of CT Perfusion abnormalities within and around spontaneous intracerebral hemorrhage during the transition from acute to subacute phases Enrico.

Acute left hemiparesis due to middle cerebral artery occlusion. A

Copyright © 2001 American Medical Association. All rights reserved.

Evidence-Base Medicine

MR Perfusion and Diffusion Values in Gliomas

Algorithm for treatment of intracranial hypertension

Icahn School of Medicine Mount Sinai Hospital

Urgent carotid intervention is safe after thrombolysis for minor to moderate acute ischemic stroke Hernan A. Bazan, MD, FACS, Nicolas Zea, MD, Bethany.

Cerebral hyperperfusion syndrome after endovascular covered stent grafting for a giant extracranial aneurysm of the internal carotid artery Sakyo Hirai,

Johnny Suh M.D., Dr. Jacobson M.D., Dr. Pond M.D.

Nat. Rev. Neurol. doi: /nrneurol

Brain computed tomography perfusion may help to detect hemodynamic reconstitution and predict intracerebral hemorrhage after carotid stenting Shy-Chyi.

Seizure - European Journal of Epilepsy

The Role of Induced Hypertension and Hyperbaric Oxygen Therapy in Moyamoya Disease: A Case Report Smeer Salam, MD; Lisa Pabst, MD; Sushil Lakhani, MD;

Michael H. Rosenthal, MD, PhD Hiroto Hatabu, MD, PhD

A 66-year-old male patient with symptomatic left intracranial carotid artery stenosis treated with balloon-mounted stenting. A 66-year-old male patient.

PC106. Characterizing Tissue Perfusion Following Lower Extremity Intervention Using 2D Color-Coded Digital Subtraction Angiography Ann H. Kim, MD, Andrew.

Figure 1 Management of acute ischaemic stroke after ICA-T occlusion

PERFUSION CT DR. DEEPIKA SOLANKI.

Tumor Segmentation from DCE-MRI with OpenCAD

A 92-year-old man presented with left hemiparesis, dysarthria, hemianopia and inattention National Institutes of Health Stroke Scale (NIHSS) 19. A 92-year-old.

A, A 50-year old female patient with acute ischemic stroke (AIS), visible as an area of reduced diffusion (dark region) on the apparent diffusion coefficient.

Three perfusion sections.

A 76-year-old man presenting with acute right-sided symptoms.

CT Perfusion Basics.

A 44-year-old male patient with symptomatic left intracranial vertebral artery stenosis treated with balloon predilation plus self-expanding stenting.

CT scans and data analysis obtained from patient 1

Presentation transcript:

Ibrain Application CT Brain Perfusion David Rodríguez González Lisbon Integration Meeting, November 2007

ibrain Lisbon Integration Meeting 13/11/2007 Introduction Collaboration between IFCA (CSIC-UC) and Hospital Universitario Marqués de Valdecilla at Santander (HUMV) radiologists. Previous collaboration Development of a tool for assisted diagnosis for brain stroke using hemodynamic parameters maps Vendor independent parameters calculation testing several methods Integration in int.eu.grid ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 Brain Stroke Brain stroke is one of the most important death and disability causes in the EU and USA. Currently available treatments could help to reduce the extension of the problem CT Perfusion techniques can help using the acquired images to generate brain maps showing relevant hemodynamical parameters: MTT Mean Transition Time BV Blood Volume BF Blood Flow But need accurate identification of the ischemic lession Other relevant information for diagnosis is needed: like angiography ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 WHAT’S STROKE? ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 NECROSIS NECROSIS PENUMBRA Core: part of the ischemic region that is irreversibly injured Penumbra: area of the brain underperfused and in danger of infarcting. ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 STROKE CT perfusion plays a major role by demonstrating salvageable brain tissue and extension of cerebral core infarction. And… WHAT’S CT PERFUSION?? ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 ANALYSIS Attenuation proportional to blood (= contrast) in brain tissue. Time attenuation curve of reference: -artery (ACA, MCA) -vein ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 CT Perfusion For DCE (Dynamic Contrast Enhancement) imaging using CT (aka CT Perfusion) a sequence of images (45) at the same location are taken in a given interval. Concertation Time Curves The objective is to get the three parameters that are related by the central volume principle This is done voxel by voxel ibrain Lisbon Integration Meeting 13/11/2007

CT Perfusion Application‏ Input: (4*) 45 CT brain images in DICOM format Using as reference an artery and a vein three parameters are computed for each pixel: blood flow (CBF), blood volume (CBV) and mean transition time (MTT). Prototype in Matlab Using RegTools Toolbox by P.C. Hansen Implemented the algorithms in ANSI C Problems with the SVD library Looking for alternatives Reimplemented in Java Using JAMA Current version being used Still some improvements needed (constrained regularization) ibrain Lisbon Integration Meeting 13/11/2007

Infarct location application Using the cerebral blood flow and the mean transit time generate a brain map showing: The infarct core The ischemic penumbra Implemented in Java (ij library for the images) Using input from GE Perfusion application Will use also our maps when finished The program fed with the parameter maps automatically calculates an output map The medic can change the criteria Also can define a good tissue region to use as reference ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 Infarct location Standalone Java GUI application To be ported to i2g as a plugin for the Migrating Desktop Would be linked to the parameter maps application Blood Flow Mean Transit Time Blood Volume ibrain Lisbon Integration Meeting 13/11/2007

ibrain Lisbon Integration Meeting 13/11/2007 Other Future Work Implementing alternative techniques for getting the perfusion and hemodynamical parameters: Frequencies filtering Parametrical approaches Bayesian Comparing all these techiques with simulated and real data Using Monte Carlo simulations to check the methods robustness against different levels of SNR ibrain Lisbon Integration Meeting 13/11/2007