Volume 12, Issue 8, Pages (August 2011)

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Volume 12, Issue 8, Pages 785-794 (August 2011) Height and cancer incidence in the Million Women Study: prospective cohort, and meta- analysis of prospective studies of height and total cancer risk Dr Jane Green, DPhil, Benjamin J Cairns, PhD, Delphine Casabonne, DPhil, F Lucy Wright, DPhil, Gillian Reeves, PhD, Prof Valerie Beral, FRS The Lancet Oncology Volume 12, Issue 8, Pages 785-794 (August 2011) DOI: 10.1016/S1470-2045(11)70154-1 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Relative risks (RRs) and 95% floated CIs (FCIs) for total incident cancer, by height RRs are adjusted for age, region, socioeconomic status, smoking, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth, and are plotted against the mean measured height in each category. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 Relative risks (RRs) and 99% CIs per 10 cm increase in height for incident cancer at 17 specific sites and for total cancer The doted line represents the RR per 10 cm increase in height for total cancer. *RRs are adjusted for age, region, socioeconomic status, smoking, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 3 Relative risks (RRs) and 99% CIs per 10 cm increase in height for all incident cancer, by various characteristics at recruitment The dotted line represents the RR per 10 cm increase in height for all women. *Standardised to the distribution of self-reported heights within each subgroup of the whole study population. †RRs are adjusted as appropriate for age, region, socioeconomic status, smoking, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 4 Relative risks (RRs) and 95% floated CIs (FCIs) for all incident cancer in relation to height, and by socioeconomic status The baseline category (RR=1·0) is women shorter than 160 cm from the highest socioeconomic group. RRs are adjusted for age, region, smoking, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth. RRs are plotted against the mean measured height in each category of height (<160 cm, 160–165 cm, 165–170 cm, ≥170 cm), within categories of socioeconomic status. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 5 Relative risks (RRs) and 99% CIs per 10 cm increase in height, for all incident cancer and for incident cancer at 17 specific sites, in never and current smokers Dotted lines represent the RR for total cancer. *RRs are adjusted for age, region, socioeconomic status, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 6 Relative risks (RRs) and 95% CIs per 10 cm increase in height for incident smoking-related and other specified cancers, in never and in current smokers *RRs are adjusted for age, region, socioeconomic status, alcohol intake, body-mass index, strenuous exercise, age at menarche, parity, and age at first birth. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 7 Meta-analysis of results from prospective studies: study-specific and summary relative risks (RRs) and 95% CIs for all cancer per 10 cm increase in height The dotted lines represent the summary RRs. NA=not available. *Mean years of birth estimated as necessary. †Includes 24% (men) and 2% (women) pipe or cigar smokers. ‡Category midpoints used to estimate mean heights in height categories. §Method of Chêne and Thompson18 used to estimate mean heights in height categories. The Lancet Oncology 2011 12, 785-794DOI: (10.1016/S1470-2045(11)70154-1) Copyright © 2011 Elsevier Ltd Terms and Conditions