Leukemogenic Activity of Cohesin Rings True Mark S. Williams, Tim C.P. Somervaille  Cell Stem Cell  Volume 17, Issue 6, Pages 642-644 (December 2015) DOI: 10.1016/j.stem.2015.11.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Cohesin Complex Mutations in Acute Myeloid Leukemia The cartoon illustrates the structure of the cohesin complex. For each component, the percentage of AML cases carrying mutations in its gene is indicated in brackets, together with the approximate proportion of truncating versus missense mutations collated from five separate studies (Cancer Genome Atlas Research Network, 2013; Kon et al., 2013; Kihara et al., 2014; Thol et al., 2014; Thota et al., 2014; n = 1,393 individuals). For ease of display, nonsense, frameshift, and splice site mutations are grouped as “truncating” mutations, and missense and inframe indels are grouped as “missense” mutations. Cell Stem Cell 2015 17, 642-644DOI: (10.1016/j.stem.2015.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions