IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus Elisha M. Singer, Daniel B. Shin,

Slides:

Advertisements

Similar presentations

NKp46-Specific Expression on Skin-Resident CD4+ Lymphocytes in Mycosis Fungoides and Sézary Syndrome Pierre Schneider, Louis-François Plassa, Philippe.

Advertisements

Neha Jariwala, Bernice Benoit, Andrew V. Kossenkov, Landon K

Increased Expression of CTLA-4 in Malignant T Cells from Patients with Mycosis Fungoides – Cutaneous T-Cell Lymphoma Henry K. Wong, Adam J. Wilson, Heather.

Impaired Responses of Peripheral Blood Mononuclear Cells to Staphylococcal Superantigen in Patients with Severe Atopic Dermatitis: A Role of T Cell Apoptosis

Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus Paul Alves, Muhammad M. Bashir, Maria Wysocka,

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15 by Maria Wysocka, Bernice M. Benoit, Sarah.

The IL-17A-Producing CD8+ T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells Marcel.

Thorbjørn Krejsgaard, Ulrik Ralfkiaer, Erik Clasen-Linde, Karsten W

Flow Cytometry Journal of Investigative Dermatology

Myeloid-Derived Suppressor Cells in Psoriasis Are an Expanded Population Exhibiting Diverse T-Cell–Suppressor Mechanisms Lauren Y. Cao, Jin-Sung Chung,

Shilpak Chatterjee, Jonathan M. Eby, Amir A

Receptor Activator of NF-κB Ligand Promotes the Production of CCL17 from RANK+ M2 Macrophages Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Masayuki.

Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ ILC3 in Psoriasis Federica Villanova, Barry Flutter,

MicroRNA Expression Profiling and DNA Methylation Signature for Deregulated MicroRNA in Cutaneous T-Cell Lymphoma Juan Sandoval, Angel Díaz-Lagares,

Nehal N. Mehta, Pradeep K. Dagur, Shawn M. Rose, Haley B

Absence of CCR4 Exacerbates Skin Inflammation in an Oxazolone-Induced Contact Hypersensitivity Model Sari Lehtimäki, Sari Tillander, Anne Puustinen,

Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy Barry Moran, Cheryl M.

Age-Related Differences in Sensitivity of Peripheral Blood Monocytes to Lipopolysaccharide and Staphylococcus Aureus Toxin B in Atopic Dermatitis Marie.

Increased Soluble CD226 in Sera of Patients with Cutaneous T-Cell Lymphoma Mediates Cytotoxic Activity against Tumor Cells via CD155 Naomi Takahashi,

Maria Wysocka, Andrew V. Kossenkov, Bernice M. Benoit, Andrea B

Liisa Väkevä, Annamari Ranki Journal of Investigative Dermatology

The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T- Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients Paola Di.

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

TSLP Directly Interacts with Skin-Homing Th2 Cells Highly Expressing its Receptor to Enhance IL-4 Production in Atopic Dermatitis Kazuki Tatsuno, Toshiharu.

Targeting PKC in Human T Cells Using Sotrastaurin (AEB071) Preserves Regulatory T Cells and Prevents IL-17 Production Xuehui He, Hans J.P.M. Koenen,

Trisia Breitkopf, Blanche K. K

IL-18, but Not IL-12, Induces Production of IFN-γ in the Immunosuppressive Environment of HPV16 E7 Transgenic Hyperplastic Skin Christina Gosmann, Ian.

Autocrine IL-21 Stimulation Is Involved in the Maintenance of Constitutive STAT3 Activation in Sézary Syndrome Leslie van der Fits, Jacoba J. Out-Luiting,

Circulating Tumor Cells and Melanoma Progression

Low Herpesvirus Entry Mediator (HVEM) Expression on Dermal Fibroblasts Contributes to a Th2-Dominant Microenvironment in Advanced Cutaneous T-Cell Lymphoma

Shelley Gorman, Melinda A. Judge, Prue H. Hart

Abnormal Natural Killer Cell Function in Systemic Sclerosis: Altered Cytokine Production and Defective Killing Activity Mayuka Horikawa, Minoru Hasegawa,

MiR-223 Regulates Cell Growth and Targets Proto-Oncogenes in Mycosis Fungoides/Cutaneous T-Cell Lymphoma Laura Y. McGirt, Clare M. Adams, Devin A. Baerenwald,

Clinical Snippets Journal of Investigative Dermatology

Minutes of the Board of Directors Meeting

Star Trek Publishing Journal of Investigative Dermatology

CD127low/- and FoxP3+ Expression Levels Characterize Different Regulatory T-Cell Populations in Human Peripheral Blood Sandra Klein, Cosima C. Kretz,

Journal of Investigative Dermatology

Chromosomally Clonal T Cells in the Skin, Blood, or Lymph Nodes of Two Sezary Syndrome Patients Express CD45RA, CD45RO, CDw150, and Interleukin-4, but.

Xue-Song Wu, Anke S. Lonsdorf, Sam T. Hwang

A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-γ for Autoreactive CD8+ T-Cell Accumulation in the Skin John E. Harris,

FOXP3+CD25− Tumor Cells with Regulatory Function in Sézary Syndrome

Dysregulation of Lymphocyte Interleukin-12 Receptor Expression in Sézary Syndrome Mohamed H. Zaki, Ryan B. Shane, Yuemei Geng, Louise C. Showe, Suzanne.

Jonathan I. Silverberg, Nanette B. Silverberg

Society for Investigative Dermatology 2010 Meeting Minutes

BJD Editor's Choice Journal of Investigative Dermatology

A.K.I. Kuroki, Masayuki Iyoda, Takanori Shibata, Tetsuzo Sugisaki

Research Snippets Journal of Investigative Dermatology

Clinical Snippets Journal of Investigative Dermatology

Journal of Investigative Dermatology

Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis Louise Newell, Marta E. Polak, Jay Perera, Charlotte Owen,

Research Snippets from the British Journal of Dermatology

Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients’ PBMCs: Potential Role for STAT-3 and NF-κB Signaling Chunlei.

25 Years of Epidermal Stem Cell Research

Progressive Upregulation of PD-1 in Primary and Metastatic Melanomas Associated with Blunted TCR Signaling in Infiltrating T Lymphocytes Maxime Chapon,

Journal of Investigative Dermatology

Decrease of Skin Infiltrating and Circulating CCR10+ T Cells Coincides with Clinical Improvement after Topical Tacrolimus in Omenn Syndrome Claudia M.

Dominance of Nonmalignant T-Cell Clones and Distortion of the TCR Repertoire in the Peripheral Blood of Patients with Cutaneous CD30+ Lymphoproliferative.

Journal of Investigative Dermatology

Machteld M. Tiemessen, Tracey J. Mitchell, Lisa Hendry, Sean J

Inhibition of IgE-Production by Peroxisome Proliferator-Activated Receptor Ligands Ralph Rühl, Anja Dahten, Florian J. Schweigert, Udo Herz, Margitta.

Interleukin-17A Promotes IgE Production in Human B Cells

S.J.P. Warren, L.A. Arteaga, L.A. Diaz

A Role for Regulatory T Cells in Cutaneous T-Cell Lymphoma; Induction of a CD4+CD25+Foxp3+ T-Cell Phenotype Associated with HTLV-1 Infection Patrick.

Variable CD7 Expression on T Cells in the Leukemic Phase of Cutaneous T Cell Lymphoma (Sézary Syndrome) Eric C. Vonderheid, Amy Kotecha, Christine M.

Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis

T Helper Type 2-Biased Natural Killer Cell Phenotype in Patients with Pemphigus Vulgaris Hayato Takahashi, Masayuki Amagai, Akiko Tanikawa, Shigeaki.

Innate Immunity Stimulates Permeability Barrier Homeostasis

Cutaneous Endothelial Cell Activation in Normal Skin of Patients with Dermatitis Herpetiformis Associated with Increased Serum Levels of IL-8, sE-Selectin,

Increased Type 2 Cytokine Expression by Both CD4+ CD45RO+ T Cells and CD8+ CD45RO+ T Cells in Blood Circulation is Associated with High Serum IgE but.

Presentation transcript:

IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus Elisha M. Singer, Daniel B. Shin, Leigh A. Nattkemper, Bernice M. Benoit, Rachel S. Klein, Chuka A. Didigu, Alison W. Loren, Tzvete Dentchev, Maria Wysocka, Gil Yosipovitch, Alain H. Rook Journal of Investigative Dermatology Volume 133, Issue 12, Pages 2783-2785 (December 2013) DOI: 10.1038/jid.2013.227 Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Peripheral blood mononuclear cell (PBMC) IL-31 mRNA and serum IL-31 correlates with marked pruritic symptoms in cutaneous T-cell lymphoma (CTCL) patients. (a) PBMCs were stimulated with phorbol 12-myristate 13-acetate (PMA)/ionomycin. IL-31 mRNA isolated from PBMCs of CTCL patients with decreasing or absent pruritus versus those with marked pruritus, P=0.006. Note that all CTCL patient mRNA values were standardized relative to the average values from a selected pool of 13 aged-matched, normal controls. Error bars: mean±SEM (n: decreasing/absent pruritus=16; marked pruritus=13). (b) Serum IL-31 levels in CTCL patients without pruritus (n=14) versus those with pruritus (n=24), P=0.0083. Error bars: mean±SEM (n: no pruritus=14; pruritus=26). Note that the linear range of the assay was 7.8pgml−1 and that all samples with a value below 7.8pgml−1 or those without any detectable IL-31 were assigned a value of 7.8pgml−1 and are colored in red. Journal of Investigative Dermatology 2013 133, 2783-2785DOI: (10.1038/jid.2013.227) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 IL-31 is produced by malignant CD4+ CD26-/CD4+ Vβ+ CTCL cells. Fifteen cutaneous T-cell lymphoma (CTCL) patients’ CD4 T cells, stimulated with phorbol 12-myristate 13-acetate (PMA)/ionomycin, were assessed for intracellular expression of IL-31 by flow cytometry. (a) Representative plots of IL-31 expression from cells without (left) and with (right) PMA/ionomycin stimulation. (b) Representative flow cytometric plot of IL-31 expression from a non-pruritic patient. (c) Representative plot of IL-31 expression from CD4+ Vβ+ CTCL cells. Journal of Investigative Dermatology 2013 133, 2783-2785DOI: (10.1038/jid.2013.227) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions