Testing the Amyloid Hypothesis with a Humanized AD Mouse Model Michelle K. Cahill, Eric J. Huang  Neuron  Volume 93, Issue 5, Pages 987-989 (March 2017) DOI: 10.1016/j.neuron.2017.02.044 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 A Schematic Diagram Showing the Selective Vulnerability of Human Neurons When Grafted into an Alzheimer’s Disease Mouse Model Although the host mouse neurons and the transplanted human neuron are exposed to Aβ amyloid plaques and to host-derived microglia and astrocytes, the human neurons exhibit more prominent degenerative features, including reduced dendritic density (tan mesh-work), and more dystrophic neurites with accumulation of synaptophysin (SYP)+ and VGlut1+ structures near Aβ amyloid plaques (yellow shaded areas). Furthermore, human neurons show evidence of necrosis, a switch to 4R tau expression, and accumulation of hyperphosphorylated tau (cyan helical structures in cytoplasm). Neuron 2017 93, 987-989DOI: (10.1016/j.neuron.2017.02.044) Copyright © 2017 Elsevier Inc. Terms and Conditions