An overview of the current status of clinical trials on endometriosis: issues and concerns  Sun-Wei Guo, Ph.D.  Fertility and Sterility  Volume 101, Issue 1, Pages 183-190.e4 (January 2014) DOI: 10.1016/j.fertnstert.2013.08.050 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Cumulative number of clinical trials registered as of July 3, 2013, as a function of the date of registration. (B) Scatter plot of 80 clinical trials registered as of July 3, 2013, by drug class. ICMJE = International Committee of Medical Journal Editors. Each bar represents one registered trial, with different colors representing different classes of drugs that the trial intended to evaluate. The ICMJE deadline was September 13, 2005, after which its journals would not publish the results of any clinical trial that had not been appropriately registered at ClinicalTrials.gov or another qualified public registry. Fertility and Sterility 2014 101, 183-190.e4DOI: (10.1016/j.fertnstert.2013.08.050) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Stacked bar plot depicting the composition of different phases of trials by sponsorship. (B) Stacked bar plot depicting the composition of different drug classes that trials intended to evaluate by sponsorship. (C) Box plot of trial sizes by sponsorship. (D) Box plot of trial duration (in months) by sponsorship. The statistical significance of the difference between the two groups is shown in the text. Fertility and Sterility 2014 101, 183-190.e4DOI: (10.1016/j.fertnstert.2013.08.050) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 (A) Stacked bar plot depicting the proportion of different trial status by sponsorship. (B) Stacked bar plot depicting the proportion of different trial status by drug class. C = classic; N = neoclassic; O = other. (C) Stacked bar plot depicting the proportion of different trial comparator by sponsorship (for phase II/III trials). (D) Stacked bar plot depicting the proportion of different trial status by the presence or absence of any positive preclinical reports on the tested compounds/drugs before the launch of the trials. Susp or S = suspended; Term or T = terminated; WD or W = withdrawn; R = recruiting; A = active; N = not recruiting. Fertility and Sterility 2014 101, 183-190.e4DOI: (10.1016/j.fertnstert.2013.08.050) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 The number of Medline-indexed publications on endometriosis by year from 1970 to 2012. The number of papers (n) for each year was searched at PubMed using the key word “endometriosis,” with the restriction of publication date in that year. The red dashed curve is the regression curve: log(n) = −101.0 + 0.05363 * year, R2 = 0.95, P=2.2 × 10−16. Fertility and Sterility 2014 101, 183-190.e4DOI: (10.1016/j.fertnstert.2013.08.050) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions