Mechanism of action of a transcription factor decoy to STAT3.

Slides:

Advertisements

Similar presentations

Goals: Discuss 3 examples of transcriptional regulation -Lac operon -Coordinated gene regulation -Regulation of transcription without regulation of polymerase.

Advertisements

JAK-STAT Signaling Pathway.

Darbepoetin alfa Drugbank ID : DB

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Cell Signaling: A Molecular View

Figure 1 Simplified scheme of TGFβ signalling

STAT3 Michael Patel.

Briefly explain the location of the cellular receptor and the mechanism of action of steroid hormones. Distinguish between synaptic, paracrine, and endocrine.

Control of Gene Expression

Diagrammatic representation of the mechanism of action of testosterone on target cells. Testosterone (T) circulates in association with sex hormone–binding.

OVERVIEW: Signals for cell surface receptors (hydrophilic):

Carcinogenic Metals International Agency for Research on Cancer (IARC) classification Group 1: Confirmed human carcinogens As, Be, Cd, Cr(VI), Ni Group.

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

Expression of Human Genes

Sustaining Proliferative Signaling and Evading Growth Suppressors

Chap. 16 Problem 1 Cytokine receptors and RTKs both form functional dimers on binding of ligand. Ligand binding activates cytosolic kinase domains which.

Laurent L'homme, PhD, David Dombrowicz, PhD

MAPK pathway inhibitors.

Volume 52, Issue 3, Pages (March 2010)

Figure 5 Defects in the JAK–STAT signalling pathway

Viruses and Cancer.

Novel nanotechnology approach to target cancer - Switch from Proto-Oncogene to Tumor Suppressor. Alexander Kazansky (Sasha)

دکتر مجیری داروساز متخصص فارماکولوژی

Figure 2 Oestrogen receptor signalling pathways

Nat. Rev. Rheumatol. doi: /nrrheum

Keratins and the Keratinocyte Activation Cycle

Figure 4 Mechanisms of leptin function on kidney injury

Figure 3 Inhibitors of the IL-6/JAK/STAT3 signalling pathway

FGFR Signaling as a Target for Lung Cancer Therapy

Selective Insulin and Leptin Resistance in Metabolic Disorders

Met as a therapeutic target in HCC: Facts and hopes

Cell Communication (Signaling) Part 3

Targeting STAT3 in hepatocellular carcinoma: Sorafenib again…

Long Noncoding RNA in Hematopoiesis and Immunity

CDK Inhibitors: Cell Cycle Regulators and Beyond

Matthew D. Daugherty, Harmit S. Malik Cell Host & Microbe

JAK/STAT Signalling: STAT Cannot Play with Ken and Barbie

Andrew Johnston Journal of Investigative Dermatology

SRC and STAT Pathways Journal of Thoracic Oncology

CeRNA networks. ceRNA networks. A, example of a ceRNET. The schematic depicts a ceRNET with a moderate degree of complexity that contains several indirect.

Volume 123, Issue 6, Pages (December 2002)

SOCS Proteins, Regulators of Intracellular Signaling

The AhR–Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention?

Lost in Translation: An Antiviral Plant Defense Mechanism Revealed

Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways. Schematic.

Mechanism-Based Precision Therapy for the Treatment of Primary Immunodeficiency and Primary Immunodysregulatory Diseases Jennifer W. Leiding, MD, Lisa.

Cell Communication (Signaling) Part 3

Increased understanding leads to increased complexity: Molecular mechanisms of pulmonary arterial hypertension Victor A. Ferraris, MD, PhD The Journal.

IL-13 receptors and signaling pathways: An evolving web

GPC5 Gene and Its Related Pathways in Lung Cancer

A, the knowledge acquired on canonical NOTCH signaling offers several targets to modulate the pathway. A, the knowledge acquired on canonical NOTCH signaling.

Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription Edward M Boyle, MD, Timothy G Canty, MD, Elizabeth N Morgan,

Figure 2 Signalling downstream of the IL-6 receptor

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases Xiaoyu Hu, Lionel B. Ivashkiv Immunity

Volume 13, Issue 11, Pages (November 2006)

Regulation of p53 by MDM2. p53 and MDM2 form an autoregulatory feedback loop. p53 stimulates the expression of MDM2; MDM2, in turn, inhibits p53 activity.

Volume 7, Issue 1, Pages 1-11 (July 1997)

Nat. Rev. Urol. doi: /nrurol

Cell Signaling: A Molecular View

Interaction of MAPJD with E-box sequence of the RIOK1 gene.

The canonical IFN-γ/JAK/STAT pathway.

A schematic representation of NOTCH signaling through DAB1–ABL–TRIO–RHO that stimulates colorectal cancer invasion and metastasis. A schematic representation.

UPR and cross-talk between apoptosis and metabolism.

Cell Signaling by Receptor Tyrosine Kinases

TYK2 signaling in T-ALL. TYK2 signaling in T-ALL. TYK2 activates STAT1 through phosphorylation downstream of the IL-10 receptor. Once phosphorylated, STAT.

Schematic demonstration of hedgehog signal pathway.

Memory Mechanisms: A common cascade for long-term memory

Overview of molecular JAK signaling.

HER2 and PI3K-targeted therapies result in FOXO3a-mediated feedback upregulation of HER3 and IGF1R and provide an escape from PI3K pathway inhibition.

Update on glucocorticoid action and resistance

Presentation transcript:

Mechanism of action of a transcription factor decoy to STAT3. Mechanism of action of a transcription factor decoy to STAT3. A, activated or tyrosine phosphorylated STAT3 dimerizes and translocates to the nucleus where it binds to specific motifs on target sequences. B, when an oligonucleotide decoy to STAT3 is injected, it is incorporated via endocytosis and sequesters activated dimeric STAT3, thus competing with sequences in the DNA, blocking transcriptional output. Priya Koppikar, and Jacqueline Bromberg Cancer Discovery 2012;2:670-672 ©2012 by American Association for Cancer Research